IGF1 |
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بنى متوفرة |
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بنك بيانات البروتين | Ortholog search: PDBe RCSB | قائمة رموز معرفات بنك بيانات البروتين | 1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS | | |
معرفات |
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أسماء بديلة | IGF1, IGF-I, A, IGFI, MGF, insulin like growth factor 1, IGF |
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معرفات خارجية | الوراثة المندلية البشرية عبر الإنترنت 147440 HomoloGene: 515 GeneCards: 3479 |
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علم الوجود الجيني |
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وظائف جزيئية | • فعالية الهرمون • insulin receptor binding • growth factor activity • integrin binding • GO:0001948، GO:0016582 ربط بروتيني • insulin-like growth factor receptor binding |
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مكونات خلوية | • الفراغ خارج الخلية • exocytic vesicle • insulin-like growth factor binding protein complex • platelet alpha granule lumen • insulin-like growth factor ternary complex • alphav-beta3 integrin-IGF-1-IGF1R complex • غشاء خلوي • خارج خلوي |
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عمليات حيوية | • positive regulation of transcription regulatory region DNA binding • skeletal system development • positive regulation of glucose import • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • تنسخ الحمض النووي الريبي منقوص الأكسجين • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • تكاثر خلوي • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • تنظيم التعبير الجيني • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • تضخم العضلات • protein kinase B signaling • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • GO:0072468 توصيل الإشارة • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني • positive regulation of cell growth involved in cardiac muscle cell development • ضبط زيادي للتكاثر الخلوي • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • GO:1901313 positive regulation of gene expression • negative regulation of gene expression • cellular response to amyloid-beta • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell apoptotic process • negative regulation of interleukin-1 beta production • negative regulation of tumor necrosis factor production • negative regulation of neuroinflammatory response • negative regulation of amyloid-beta formation |
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المصادر:Amigo / QuickGO | |
نمط التعبير عن الحمض النووي الريبوزي |
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المزيد من بيانات التعبير المرجعية |
تماثلات متسلسلة |
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أنواع | الإنسان | الفأر |
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أنتريه | 3479 | 24482 |
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Ensembl | ENSG00000017427 | ENSRNOG00000004517 |
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يونيبروت | | |
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RefSeq (رنا مرسال.) | | NM_001111283، NM_001111284، NM_001111285، XM_017019259، XM_017019261، XM_017019262، XM_017019263 NM_000618، NM_001111283، NM_001111284، NM_001111285، XM_017019259، XM_017019261، XM_017019262، XM_017019263 |
| | NM_001082478، NM_001082479، NM_178866، XM_006241191، XM_006241193، XM_006241194، XM_039078401، XM_039078402 NM_001082477، NM_001082478، NM_001082479، NM_178866، XM_006241191، XM_006241193، XM_006241194، XM_039078401، XM_039078402 |
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RefSeq (بروتين) | | NP_001104753، NP_001104754، NP_001104755، XP_016874748، XP_016874750، XP_016874751، XP_016874752 NP_000609، NP_001104753، NP_001104754، NP_001104755، XP_016874748، XP_016874750، XP_016874751، XP_016874752 |
| | NP_001075947، NP_001075948، NP_849197، XP_006241253، XP_006241255، XP_006241256، XP_038934329، XP_038934330 NP_001075946، NP_001075947، NP_001075948، NP_849197، XP_006241253، XP_006241255، XP_006241256، XP_038934329، XP_038934330 |
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الموقع (UCSC | n/a | norvegicus 7:22282930-22359296 Chr Rattus norvegicus 7: 22.28 – 22.36 Mb |
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بحث ببمد | [1] | [2] |
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ويكي بيانات |
اعرض/عدّل إنسان | اعرض/عدّل فأر |
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