3-Methyl-GABA
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IUPAC name 4-Amino-3-methylbutanoic acid | |
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Properties | |
Chemical formula | C5H11NO2 |
Molar mass | 117.148 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
3-Methyl-GABA, also known as HMS3266K11, is an anticonvulsant alkaloid.
Pharmacology
3-Methyl-GABA is an activator of GABA-T, an enzyme that transforms GABA to succinate semialdehyde and glutamate.[1]
It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.[2][3]
References
- ^ https://www.tocris.com/products/3-methyl-gaba_0386
- ^ https://www.medchemexpress.com/3-methyl-gaba.html
- ^ Silverman, Richard B.; Andruszkiewicz, Ryszard; Nanavati, Shrenik M.; Taylor, Charles P.; Vartanian, Mark G. (1991). "3-Alkyl-4-aminobutyric acids: The first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.
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GABATooltip γ-Aminobutyric acid metabolism and transport modulators
GATTooltip GABA transporter |
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VIAATTooltip Vesicular inhibitory amino acid transporter |
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GADTooltip Glutamate decarboxylase |
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GABA-TTooltip γ-Aminobutyrate aminotransferase |
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Antivitamin B6 |
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- See also
- Receptor/signaling modulators
- GABA receptor modulators
- GABAA receptor positive modulators
- Glutamate metabolism/transport modulators