6-Phosphogluconic acid
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IUPAC name 6-O-Phosphono-D-gluconic acid | |
Systematic IUPAC name (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(phosphonooxy)hexanoic acid | |
Other names 6-Phosphogluconate | |
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ECHA InfoCard | 100.011.882 |
MeSH | 6-phosphogluconate |
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Properties | |
Chemical formula | C6H13O10P |
Molar mass | 276.135 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
6-Phosphogluconic acid (with conjugate base 6-phosphogluconate) is a phosphorylated sugar acid which appears in the pentose phosphate pathway and the Entner–Doudoroff pathway.
During the oxidative phase of the pentose phosphate pathway, it is formed from 6-phosphogluconolactone by 6-phosphogluconolactonase, and in turn, it is converted to ribulose 5-phosphate by phosphogluconate dehydrogenase, in an oxidative decarboxylation which also produces NADPH.
In those microorganisms which host the Entner-Doudoroff pathway, 6-phosphogluconic acid may also be acted upon by 6-phosphogluconate dehydratase to produce 2-keto-3-deoxy-6-phosphogluconate.
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- 6-Phosphogluconolactone
- 6-Phosphogluconate
- Ribulose 5-phosphate
- Ribose 5-phosphate
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