APBB2

Protein-coding gene in the species Homo sapiens

APBB2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1WGU, 2ROZ, 2YSZ, 2YT0, 2YT1

Identifiers

Aliases

APBB2, FE65L, FE65L1, amyloid beta precursor protein binding family B member 2

External IDs

OMIM: 602710; MGI: 108405; HomoloGene: 32079; GeneCards: APBB2; OMA:APBB2 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p14-p13	Start	40,810,027 bp^[1]
Band	4p14-p13	End	41,216,714 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 C3.1	Start	66,456,046 bp^[2]
Band	5\|5 C3.1	End	66,776,127 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

Achilles tendon

sural nerve

dorsal motor nucleus of vagus nerve

inferior olivary nucleus

tendon of biceps brachii

internal globus pallidus

ventricular zone

corpus callosum

tibia

Top expressed in

genital tubercle

lateral geniculate nucleus

renal corpuscle

medial dorsal nucleus

pontine nuclei

ankle

triceps brachii muscle

deep cerebellar nuclei

lateral septal nucleus

medial geniculate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding transcription factor binding amyloid-beta binding
Cellular component	growth cone membrane cytoplasm lamellipodium synapse nucleus
Biological process	positive regulation of apoptotic process intracellular signal transduction negative regulation of cell growth negative regulation of apoptotic process extracellular matrix organization axon guidance neuron migration regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


323


11787

Ensembl


ENSG00000163697


ENSMUSG00000029207

UniProt


Q92870


Q9DBR4

RefSeq (mRNA)

NM_001166050 NM_001166051 NM_001166052 NM_001166053 NM_001166054
NM_004307 NM_173075 NM_001330656 NM_001330658

NM_001201413 NM_001201414 NM_001201415 NM_001201416 NM_009686
NM_001310626

RefSeq (protein)

NP_001159522 NP_001159523 NP_001159524 NP_001159525 NP_001159526
NP_001317585 NP_001317587 NP_004298 NP_775098

NP_001188342 NP_001188343 NP_001188344 NP_001188345 NP_001297555
NP_033816

Location (UCSC)

Chr 4: 40.81 – 41.22 Mb

Chr 5: 66.46 – 66.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.^[5]^[6]^[7]

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163697 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029207 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.
^ Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM (Jun 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome. 9 (6): 473–5. doi:10.1007/s003359900800. PMID 9585438. S2CID 31066473.
^ ^a ^b "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)".

External links

Human APBB2 genome location and APBB2 gene details page in the UCSC Genome Browser.

Guénette SY, Chen J, Jondro PD, Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. Bibcode:1996PNAS...9310832G. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266.
Bruni P, Minopoli G, Brancaccio T, et al. (2002). "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression". J. Biol. Chem. 277 (38): 35481–8. doi:10.1074/jbc.M205227200. PMID 12089154.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chang Y, Tesco G, Jeong WJ, et al. (2004). "Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1". J. Biol. Chem. 278 (51): 51100–7. doi:10.1074/jbc.M309561200. PMID 14527950.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Li Y, Hollingworth P, Moore P, et al. (2006). "Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease". Hum. Mutat. 25 (3): 270–7. doi:10.1002/humu.20138. PMID 15714520. S2CID 28343972.
Lange A, Thon L, Mathieu S, Adam D (2005). "The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor". Biochem. Biophys. Res. Commun. 335 (2): 575–83. doi:10.1016/j.bbrc.2005.07.125. PMID 16083851.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hong Q, Hsu LJ, Schultz L, et al. (2007). "Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response". BMC Mol. Biol. 8: 50. doi:10.1186/1471-2199-8-50. PMC 1904229. PMID 17567906.