APPL2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4H8S, 5C5B |
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Identifiers |
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Aliases | APPL2, DIP13B, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 |
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External IDs | OMIM: 606231; MGI: 2384914; HomoloGene: 10046; GeneCards: APPL2; OMA:APPL2 - orthologs |
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Gene location (Human) |
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![Chromosome 12 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/300px-Ideogram_human_chromosome_12.svg.png) | Chr. | Chromosome 12 (human)[1] |
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| Band | 12q23.3 | Start | 105,173,297 bp[1] |
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End | 105,236,203 bp[1] |
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Gene location (Mouse) |
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![Chromosome 10 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10|10 C1 | Start | 83,435,897 bp[2] |
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End | 83,484,602 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - skin of leg
- skin of abdomen
- rectum
- mucosa of transverse colon
- ventricular zone
- Achilles tendon
- stromal cell of endometrium
- canal of the cervix
- ectocervix
- bronchial epithelial cell
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| Top expressed in | - retinal pigment epithelium
- ciliary body
- iris
- cerebellar cortex
- neural layer of retina
- parotid gland
- lobe of cerebellum
- cerebellar vermis
- lacrimal gland
- epithelium of stomach
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b2/PBB_GE_APPL2_218218_at_fs.png/250px-PBB_GE_APPL2_218218_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - protein binding
- phosphatidylserine binding
- phosphatidylinositol binding
- protein homodimerization activity
- protein-containing complex binding
| Cellular component | - cytoplasm
- NuRD complex
- endosome
- early endosome membrane
- endosome membrane
- extracellular exosome
- membrane
- nucleus
- ruffle
- plasma membrane
- cytoplasmic vesicle
- vesicle
- early phagosome
- ruffle membrane
- early phagosome membrane
- macropinosome
- phagocytic vesicle membrane
- cell projection
- phagocytic vesicle
| Biological process | - cell cycle
- cell population proliferation
- signal transduction
- diet induced thermogenesis
- transforming growth factor beta receptor signaling pathway
- cold acclimation
- regulation of fibroblast migration
- signaling
- adiponectin-activated signaling pathway
- regulation of toll-like receptor 4 signaling pathway
- cellular response to hepatocyte growth factor stimulus
- glucose homeostasis
- regulation of innate immune response
- negative regulation of fatty acid oxidation
- negative regulation of glucose import
- negative regulation of neurogenesis
- protein homotetramerization
- positive regulation of phagocytosis, engulfment
- positive regulation of cold-induced thermogenesis
- negative regulation of cytokine production involved in inflammatory response
- negative regulation of cellular response to insulin stimulus
- positive regulation of macropinocytosis
- positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
- negative regulation of neural precursor cell proliferation
- protein import into nucleus
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001251904 NM_001251905 NM_018171 |
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RefSeq (protein) | |
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NP_001238833 NP_001238834 NP_060641 |
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Location (UCSC) | Chr 12: 105.17 – 105.24 Mb | Chr 10: 83.44 – 83.48 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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