APPL2

Protein-coding gene in the species Homo sapiens
APPL2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4H8S, 5C5B

Identifiers
AliasesAPPL2, DIP13B, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
External IDsOMIM: 606231; MGI: 2384914; HomoloGene: 10046; GeneCards: APPL2; OMA:APPL2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for APPL2
Genomic location for APPL2
Band12q23.3Start105,173,297 bp[1]
End105,236,203 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for APPL2
Genomic location for APPL2
Band10|10 C1Start83,435,897 bp[2]
End83,484,602 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of leg

  • skin of abdomen

  • rectum

  • mucosa of transverse colon

  • ventricular zone

  • Achilles tendon

  • stromal cell of endometrium

  • canal of the cervix

  • ectocervix

  • bronchial epithelial cell
Top expressed in
  • retinal pigment epithelium

  • ciliary body

  • iris

  • cerebellar cortex

  • neural layer of retina

  • parotid gland

  • lobe of cerebellum

  • cerebellar vermis

  • lacrimal gland

  • epithelium of stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • phosphatidylserine binding
  • phosphatidylinositol binding
  • protein homodimerization activity
  • protein-containing complex binding
Cellular component
  • cytoplasm
  • NuRD complex
  • endosome
  • early endosome membrane
  • endosome membrane
  • extracellular exosome
  • membrane
  • nucleus
  • ruffle
  • plasma membrane
  • cytoplasmic vesicle
  • vesicle
  • early phagosome
  • ruffle membrane
  • early phagosome membrane
  • macropinosome
  • phagocytic vesicle membrane
  • cell projection
  • phagocytic vesicle
Biological process
  • cell cycle
  • cell population proliferation
  • signal transduction
  • diet induced thermogenesis
  • transforming growth factor beta receptor signaling pathway
  • cold acclimation
  • regulation of fibroblast migration
  • signaling
  • adiponectin-activated signaling pathway
  • regulation of toll-like receptor 4 signaling pathway
  • cellular response to hepatocyte growth factor stimulus
  • glucose homeostasis
  • regulation of innate immune response
  • negative regulation of fatty acid oxidation
  • negative regulation of glucose import
  • negative regulation of neurogenesis
  • protein homotetramerization
  • positive regulation of phagocytosis, engulfment
  • positive regulation of cold-induced thermogenesis
  • negative regulation of cytokine production involved in inflammatory response
  • negative regulation of cellular response to insulin stimulus
  • positive regulation of macropinocytosis
  • positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
  • negative regulation of neural precursor cell proliferation
  • protein import into nucleus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55198

216190

Ensembl

ENSG00000136044

ENSMUSG00000020263

UniProt

Q8NEU8

Q8K3G9

RefSeq (mRNA)

NM_001251904
NM_001251905
NM_018171

NM_145220

RefSeq (protein)

NP_001238833
NP_001238834
NP_060641

NP_660255

Location (UCSC)Chr 12: 105.17 – 105.24 MbChr 10: 83.44 – 83.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DCC-interacting protein 13-beta is a protein that in humans is encoded by the APPL2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136044 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020263 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bonaglia MC, Giorda R, Borgatti R, Felisari G, Gagliardi C, Selicorni A, Zuffardi O (Jul 2001). "Disruption of the ProSAP2 Gene in a t(12;22)(q24.1;q13.3) Is Associated with the 22q13.3 Deletion Syndrome". Am J Hum Genet. 69 (2): 261–8. doi:10.1086/321293. PMC 1235301. PMID 11431708.
  6. ^ Nechamen CA, Thomas RM, Dias JA (Nov 2006). "APPL1, APPL2, Akt2 and FOXO1a Interact with FSHR in a Potential Signaling Complex". Mol Cell Endocrinol. 260–262: 93–9. doi:10.1016/j.mce.2006.08.014. PMC 1782224. PMID 17030088.
  7. ^ "Entrez Gene: APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2".

Further reading

  • Mao X, Kikani CK, Riojas RA, et al. (2006). "APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function". Nat. Cell Biol. 8 (5): 516–23. doi:10.1038/ncb1404. PMID 16622416. S2CID 21273764.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Miaczynska M, Christoforidis S, Giner A, et al. (2004). "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment". Cell. 116 (3): 445–56. doi:10.1016/S0092-8674(04)00117-5. PMID 15016378. S2CID 18281503.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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