ARHGAP24

Protein-coding gene in the species Homo sapiens
ARHGAP24
Identifiers
AliasesARHGAP24, FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP, Rho GTPase activating protein 24
External IDsOMIM: 610586; MGI: 1922647; HomoloGene: 32754; GeneCards: ARHGAP24; OMA:ARHGAP24 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ARHGAP24
Genomic location for ARHGAP24
Band4q21.23-q21.3Start85,475,150 bp[1]
End86,002,668 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for ARHGAP24
Genomic location for ARHGAP24
Band5|5 E5Start102,629,257 bp[2]
End103,045,803 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • pons

  • parotid gland

  • sural nerve

  • pylorus

  • human kidney

  • epithelium of colon

  • vena cava

  • cardia

  • Achilles tendon
Top expressed in
  • epithelium of lens

  • right kidney

  • sciatic nerve

  • human kidney

  • renal cortex

  • proximal tubule

  • rib

  • inner renal medulla

  • neural layer of retina

  • soleus muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • GTPase activator activity
Cellular component
  • cytoplasm
  • cytosol
  • adherens junction
  • cell junction
  • cell projection
  • cytoskeleton
  • focal adhesion
Biological process
  • multicellular organism development
  • positive regulation of GTPase activity
  • cell differentiation
  • regulation of small GTPase mediated signal transduction
  • angiogenesis
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83478

231532

Ensembl

ENSG00000138639

ENSMUSG00000057315

UniProt

Q8N264

Q8C4V1

RefSeq (mRNA)

NM_001025616
NM_001042669
NM_001287805
NM_031305
NM_001346093

NM_001286468
NM_029270
NM_146161
NM_001346585

RefSeq (protein)

NP_001020787
NP_001036134
NP_001274734
NP_001333022
NP_112595

NP_001273397
NP_001333514
NP_083546
NP_666273

Location (UCSC)Chr 4: 85.48 – 86 MbChr 5: 102.63 – 103.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138639 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057315 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ Katoh M, Katoh M (Aug 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". International Journal of Molecular Medicine. 14 (2): 333–8. doi:10.3892/ijmm.14.2.333. PMID 15254788.
  7. ^ "Entrez Gene: ARHGAP24 Rho GTPase activating protein 24".

Further reading

  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Lee SY, Obata Y, Yoshida M, Stockert E, Williamson B, Jungbluth AA, Chen YT, Old LJ, Scanlan MJ (Mar 2003). "Immunomic analysis of human sarcoma". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2651–2656. Bibcode:2003PNAS..100.2651L. doi:10.1073/pnas.0437972100. PMC 151395. PMID 12601173.
  • Su ZJ, Hahn CN, Goodall GJ, Reck NM, Leske AF, Davy A, Kremmidiotis G, Vadas MA, Gamble JR (Aug 2004). "A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12212–12217. Bibcode:2004PNAS..10112212S. doi:10.1073/pnas.0404631101. PMC 514459. PMID 15302923.
  • Lavelin I, Geiger B (Feb 2005). "Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton". The Journal of Biological Chemistry. 280 (8): 7178–7185. doi:10.1074/jbc.M411990200. PMID 15611138.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ohta Y, Hartwig JH, Stossel TP (Aug 2006). "FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling". Nature Cell Biology. 8 (8): 803–814. doi:10.1038/ncb1437. PMID 16862148. S2CID 5754772.


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