ARHGAP25

Protein-coding gene in the species Homo sapiens
ARHGAP25
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1V89

Identifiers
AliasesARHGAP25, HEL-S-308, KAIA0053, Rho GTPase activating protein 25
External IDsOMIM: 610587; MGI: 2443687; HomoloGene: 45507; GeneCards: ARHGAP25; OMA:ARHGAP25 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ARHGAP25
Genomic location for ARHGAP25
Band2p13.3Start68,679,601 bp[1]
End68,826,833 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for ARHGAP25
Genomic location for ARHGAP25
Band6|6 D1Start87,435,527 bp[2]
End87,510,241 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • blood

  • spleen

  • lymph node

  • monocyte

  • bone marrow cells

  • appendix

  • periodontal fiber

  • tonsil

  • epithelium of colon
Top expressed in
  • granulocyte

  • mesenteric lymph nodes

  • spleen

  • thymus

  • bone marrow

  • blood

  • lumbar spinal ganglion

  • stroma of bone marrow

  • subcutaneous adipose tissue

  • middle ear
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • GTPase activator activity
Cellular component
  • cytosol
  • phagocytic cup
Biological process
  • positive regulation of GTPase activity
  • regulation of small GTPase mediated signal transduction
  • signal transduction
  • phagocytosis, engulfment
  • actin filament organization
  • negative regulation of small GTPase mediated signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9938

232201

Ensembl

ENSG00000163219

ENSMUSG00000030047

UniProt

P42331

Q8BYW1

RefSeq (mRNA)
NM_001007231
NM_001166276
NM_001166277
NM_014882
NM_001364819

NM_001364820
NM_001364821

NM_001037727
NM_001286610
NM_175476

RefSeq (protein)
NP_001007232
NP_001159748
NP_001159749
NP_055697
NP_001351748

NP_001351749
NP_001351750

NP_001032816
NP_001273539
NP_780685

Location (UCSC)Chr 2: 68.68 – 68.83 MbChr 6: 87.44 – 87.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene.[5] The gene is also known as KAIA0053.[5] ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell polarity, and cell migration.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163219 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030047 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Rho GTPase activating protein 25". Retrieved 2011-12-05.
  6. ^ Katoh M, Katoh M (August 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". International Journal of Molecular Medicine. 14 (2): 333–8. doi:10.3892/ijmm.14.2.333. PMID 15254788.

Further reading

  • Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K (January 2010). "Mutation of ARHGAP9 in patients with coronary spastic angina". Journal of Human Genetics. 55 (1): 42–9. doi:10.1038/jhg.2009.120. PMID 19911011.
  • Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
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