ARHGAP27

Protein-coding gene in the species Homo sapiens
ARHGAP27
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3PP2

Identifiers
AliasesARHGAP27, CAMGAP1, PP905, SH3D20, SH3P20, Rho GTPase activating protein 27
External IDsOMIM: 610591; MGI: 1916903; HomoloGene: 45715; GeneCards: ARHGAP27; OMA:ARHGAP27 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ARHGAP27
Genomic location for ARHGAP27
Band17q21.31Start45,393,902 bp[1]
End45,434,421 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for ARHGAP27
Genomic location for ARHGAP27
Band11|11 E1Start103,222,323 bp[2]
End103,254,518 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • blood

  • monocyte

  • mucosa of transverse colon

  • spleen

  • duodenum

  • appendix

  • minor salivary glands

  • vagina

  • upper lobe of left lung
Top expressed in
  • granulocyte

  • pyloric antrum

  • otic vesicle

  • esophagus

  • right kidney

  • gastric mucosa

  • yolk sac

  • epithelium of stomach

  • lip

  • fibula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • SH3 domain binding
  • GTPase activator activity
Cellular component
  • intracellular anatomical structure
  • membrane
  • nucleus
  • nucleoplasm
  • cytoplasm
  • cytosol
Biological process
  • endocytosis
  • signal transduction
  • positive regulation of GTPase activity
  • receptor-mediated endocytosis
  • regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

201176

544817

Ensembl

ENSG00000159314
ENSG00000276836
ENSG00000276907

ENSMUSG00000034255

UniProt

Q6ZUM4
Q8N2Y9

A2AB59

RefSeq (mRNA)

NM_001159330
NM_001282290
NM_174919
NM_199282

NM_001205236
NM_133715
NM_183288

RefSeq (protein)

NP_001269219
NP_777579
NP_954976
NP_954976.1

NP_001192165
NP_598476
NP_899111

Location (UCSC)Chr 17: 45.39 – 45.43 MbChr 11: 103.22 – 103.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPase activating protein 27 is a protein that in humans is encoded by the ARHGAP27 gene. [5]

Function

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may play a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013].

References

  1. ^ a b c ENSG00000276836, ENSG00000276907 GRCh38: Ensembl release 89: ENSG00000159314, ENSG00000276836, ENSG00000276907 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034255 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Rho GTPase activating protein 27". Retrieved 2018-05-30.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Rho GTPase-activating protein 27 (ARHGAP27)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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