ARHGAP9

Protein-coding gene in humans

ARHGAP9

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
2P0D, 2P0H

Identifiers

Aliases

ARHGAP9, 10C, RGL1, Rho GTPase activating protein 9

External IDs

OMIM: 610576; MGI: 2143764; HomoloGene: 13041; GeneCards: ARHGAP9; OMA:ARHGAP9 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.3	Start	57,472,264 bp^[1]
Band	12q13.3	End	57,488,814 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D3	Start	127,157,833 bp^[2]
Band	10\|10 D3	End	127,165,812 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

blood

spleen

appendix

monocyte

lymph node

bone marrow

bone marrow cells

trabecular bone

mucosa of ileum

Top expressed in

granulocyte

mesenteric lymph nodes

blood

thymus

bone marrow

spleen

tibiofemoral joint

submandibular gland

parotid gland

stroma of bone marrow

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding phosphatidylinositol-3,4,5-trisphosphate binding lipid binding GTPase activator activity
Cellular component	cytosol extracellular region secretory granule lumen cytoplasm
Biological process	regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity neutrophil degranulation regulation of GTPase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64333


216445

Ensembl


ENSG00000123329


ENSMUSG00000040345

UniProt


Q9BRR9


n/a

RefSeq (mRNA)

NM_001080156 NM_001080157 NM_032496 NM_001319850 NM_001319851
NM_001319852 NM_001367422 NM_001367423 NM_001367424 NM_001367425 NM_001367426


NM_001285785 NM_146011 NM_001359656 NM_001359657

RefSeq (protein)

NP_001073625 NP_001073626 NP_001306779 NP_001306780 NP_001306781
NP_115885 NP_001354351 NP_001354352 NP_001354353 NP_001354354 NP_001354355 NP_001306779.1


n/a

Location (UCSC)

Chr 12: 57.47 – 57.49 Mb

Chr 10: 127.16 – 127.17 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.^[5]^[6]

Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123329 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040345 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.
^ ^a ^b "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

External links

Human ARHGAP9 genome location and ARHGAP9 gene details page in the UCSC Genome Browser.
Human RGL1 genome location and RGL1 gene details page in the UCSC Genome Browser.

Peck J, Douglas G, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Letters. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274. S2CID 30443852.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.