ARHGEF3

Protein-coding gene in the species Homo sapiens
ARHGEF3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2Z0Q

Identifiers
AliasesARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3
External IDsOMIM: 612115; MGI: 1918954; HomoloGene: 41329; GeneCards: ARHGEF3; OMA:ARHGEF3 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ARHGEF3
Genomic location for ARHGEF3
Band3p14.3Start56,727,418 bp[1]
End57,079,329 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for ARHGEF3
Genomic location for ARHGEF3
Band14 A3|14 16.09 cMStart26,836,856 bp[2]
End27,125,868 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • glomerulus

  • metanephric glomerulus

  • endothelial cell

  • Epithelium of choroid plexus

  • Brodmann area 23

  • germinal epithelium

  • middle temporal gyrus

  • granulocyte

  • oral cavity

  • parietal pleura
Top expressed in
  • granulocyte

  • lobe of cerebellum

  • pontine nuclei

  • cerebellar vermis

  • right lung

  • right lung lobe

  • subiculum

  • deep cerebellar nuclei

  • olfactory tubercle

  • lateral septal nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • cytosol
  • intracellular anatomical structure
Biological process
  • regulation of Rho protein signal transduction
  • intracellular signal transduction
  • regulation of small GTPase mediated signal transduction
  • Rho protein signal transduction
  • positive regulation of apoptotic process
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50650

71704

Ensembl

ENSG00000163947

ENSMUSG00000021895

UniProt

Q9NR81

Q91X46

RefSeq (mRNA)
NM_001128615
NM_001128616
NM_001289698
NM_019555
NM_001377407

NM_001377408
NM_001377409
NM_001377410
NM_001377411
NM_001377412
NM_001377413
NM_001377414
NM_001377415

NM_001289686
NM_001289687
NM_001289688
NM_027871

RefSeq (protein)
NP_001122087
NP_001122088
NP_001276627
NP_062455
NP_001364336

NP_001364337
NP_001364338
NP_001364339
NP_001364340
NP_001364341
NP_001364342
NP_001364343
NP_001364344

NP_001276615
NP_001276616
NP_001276617
NP_082147

Location (UCSC)Chr 3: 56.73 – 57.08 MbChr 14: 26.84 – 27.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.[5]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.[5]

Interactions

ARHGEF3 has been shown to interact with RHOA[6] and RHOB.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163947 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021895 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".
  6. ^ a b Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Thiesen S, Kübart S, Ropers HH, Nothwang HG (2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem. Biophys. Res. Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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