ARHGEF4

Protein-coding gene in the species Homo sapiens

ARHGEF4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DX1, 2PZ1, 3NMX, 3NMZ

Identifiers
AliasesARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
External IDsOMIM: 605216; MGI: 2442507; HomoloGene: 49414; GeneCards: ARHGEF4; OMA:ARHGEF4 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ARHGEF4
Genomic location for ARHGEF4
Band2q21.1Start130,836,914 bp[1]
End131,047,263 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ARHGEF4
Genomic location for ARHGEF4
Band1|1 BStart34,678,188 bp[2]
End34,813,309 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • nucleus accumbens

  • prefrontal cortex

  • Brodmann area 9

  • cingulate gyrus

  • anterior cingulate cortex

  • amygdala

  • putamen

  • caudate nucleus

  • Brodmann area 10
Top expressed in
  • central gray substance of midbrain

  • pontine nuclei

  • dorsal tegmental nucleus

  • anterior horn of spinal cord

  • medial vestibular nucleus

  • superior colliculus

  • hippocampus proper

  • dentate gyrus

  • facial motor nucleus

  • nucleus of stria terminalis
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein domain specific binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • ruffle membrane
  • cytosol
  • plasma membrane
  • cell projection
  • membrane
Biological process
  • filopodium assembly
  • regulation of Rho protein signal transduction
  • intracellular signal transduction
  • regulation of small GTPase mediated signal transduction
  • lamellipodium assembly
  • positive regulation of apoptotic process
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50649

226970

Ensembl

ENSG00000136002

ENSMUSG00000037509

UniProt

Q9NR80

Q7TNR9

RefSeq (mRNA)
NM_015320
NM_032995
NM_001367493
NM_001375900
NM_001375901

NM_001375902
NM_001375903
NM_001375904
NM_001395416

NM_183019
NM_001368773

RefSeq (protein)
NP_056135
NP_001354422
NP_001362829
NP_001362830
NP_001362831

NP_001362832
NP_001362833

NP_898840
NP_001355702

Location (UCSC)Chr 2: 130.84 – 131.05 MbChr 1: 34.68 – 34.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.[5][6]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene.[6]

Interactions

ARHGEF4 has been shown to interact with APC.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136002 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037509 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thiesen S, Kübart S, Ropers HH, Nothwang HG (Jul 2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem Biophys Res Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
  6. ^ a b "Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4".
  7. ^ Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, et al. (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID 10947987.

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, et al. (2006). "Adenomatous polyposis coli (APC) is required for normal development of skin and thymus". PLOS Genet. 2 (9): e146. doi:10.1371/journal.pgen.0020146. PMC 1564426. PMID 17002498.
  • Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, et al. (2005). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration". Dev. Cell. 7 (6): 871–83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.
  • Kawasaki Y, Sato R, Akiyama T (2003). "Mutated APC and Asef are involved in the migration of colorectal tumour cells". Nat. Cell Biol. 5 (3): 211–5. doi:10.1038/ncb937. PMID 12598901. S2CID 22276128.
  • Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, et al. (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID 10947987.
  • v
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  • e
  • 2dx1: Crystal structure of RhoGEF protein Asef
    2dx1: Crystal structure of RhoGEF protein Asef


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