ARL4A

Protein-coding gene in the species Homo sapiens

ARL4A
Identifiers
AliasesARL4A, ARL4, ADP ribosylation factor like GTPase 4A
External IDsOMIM: 604786; MGI: 99437; HomoloGene: 4194; GeneCards: ARL4A; OMA:ARL4A - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ARL4A
Genomic location for ARL4A
Band7p21.3Start12,686,856 bp[1]
End12,690,958 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for ARL4A
Genomic location for ARL4A
Band12 B1|12 18.06 cMStart40,055,446 bp[2]
End40,088,024 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • skin of abdomen

  • olfactory zone of nasal mucosa

  • mucosa of transverse colon

  • skin of leg

  • vagina

  • Achilles tendon

  • rectum

  • bone marrow
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • decidua

  • ascending aorta

  • brown adipose tissue

  • gastrula

  • skin of external ear

  • white adipose tissue

  • intercostal muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
Cellular component
  • plasma membrane
  • nucleolus
  • intracellular anatomical structure
  • membrane
  • nucleus
  • nucleoplasm
  • cytoplasm
  • cytosol
Biological process
  • brown fat cell differentiation
  • intracellular protein transport
  • vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10124

11861

Ensembl

ENSG00000122644

ENSMUSG00000047446

UniProt

P40617

P61213

RefSeq (mRNA)

NM_212460
NM_001037164
NM_001195396
NM_005738

NM_001039515
NM_007487

RefSeq (protein)

NP_001032241
NP_001182325
NP_005729
NP_997625

NP_001034604
NP_031513

Location (UCSC)Chr 7: 12.69 – 12.69 MbChr 12: 40.06 – 40.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.[5]

Function

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.[5]

Interactions

ARL4A has been shown to interact with Karyopherin alpha 2.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122644 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047446 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A".
  6. ^ Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.

Further reading

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
  • Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG (1999). "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal". FEBS Lett. 456 (3): 384–8. doi:10.1016/S0014-5793(99)00759-0. PMID 10462049. S2CID 84422541.
  • Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (2001). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.
  • Hofmann I, Thompson A, Sanderson CM, Munro S (2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane". Curr. Biol. 17 (8): 711–6. Bibcode:2007CBio...17..711H. doi:10.1016/j.cub.2007.03.007. PMID 17398095. S2CID 1341183.


  • v
  • t
  • e