ASB13

Protein-coding gene in the species Homo sapiens

ASB13
Identifiers
AliasesASB13, ankyrin repeat and SOCS box containing 13
External IDsOMIM: 615055; MGI: 2145525; HomoloGene: 11666; GeneCards: ASB13; OMA:ASB13 - orthologs
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[1]
Chromosome 13 (mouse)
Genomic location for ASB13
Genomic location for ASB13
Band13|13 A1Start3,684,032 bp[1]
End3,703,822 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • right lobe of liver

  • kidney tubule

  • gastric mucosa

  • kidney

  • tibia

  • duodenum

  • metanephric glomerulus

  • Brodmann area 9

  • prefrontal cortex
Top expressed in
  • deep cerebellar nuclei

  • medial vestibular nucleus

  • pontine nuclei

  • dorsal tegmental nucleus

  • medial geniculate nucleus

  • lateral geniculate nucleus

  • inferior colliculus

  • globus pallidus

  • medial dorsal nucleus

  • superior colliculus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytosol
Biological process
  • protein ubiquitination
  • intracellular signal transduction
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79754

142688

Ensembl

n/a

ENSMUSG00000033781

UniProt

Q8WXK3

Q8VBX0

RefSeq (mRNA)

NM_024701

NM_001267724
NM_178283

RefSeq (protein)

NP_078977

NP_001254653
NP_840068

Location (UCSC)n/aChr 13: 3.68 – 3.7 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Ankyrin repeat and SOCS box protein 13 is a protein that in humans is encoded by the ASB13 gene.[4][5]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length sequences are not known.[5]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033781 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  5. ^ a b "Entrez Gene: ASB13 ankyrin repeat and SOCS box-containing 13".

Further reading

  • Kohroki J, Nishiyama T, Nakamura T, Masuho Y (2006). "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes". FEBS Lett. 579 (30): 6796–802. doi:10.1016/j.febslet.2005.11.016. PMID 16325183. S2CID 7196353.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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