Protein-coding gene in the species Homo sapiens
ADIPOR2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | ADIPOR2, adiponectin receptor 2, ACDCR2, PAQR2 |
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External IDs | OMIM: 607946; MGI: 93830; HomoloGene: 56119; GeneCards: ADIPOR2; OMA:ADIPOR2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12p13.33 | Start | 1,688,574 bp[1] |
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End | 1,788,674 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 6 (mouse)[2] |
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| Band | 6 F1|6 56.78 cM | Start | 119,330,111 bp[2] |
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End | 119,394,665 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - corpus callosum
- C1 segment
- right adrenal cortex
- right lung
- left adrenal gland
- left adrenal cortex
- substantia nigra
- liver
- epithelium of colon
- hippocampus proper
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| Top expressed in | - lactiferous gland
- brown adipose tissue
- transitional epithelium of urinary bladder
- vestibular membrane of cochlear duct
- epithelium of small intestine
- epithelium of stomach
- pyloric antrum
- left lobe of liver
- white adipose tissue
- tunica adventitia of aorta
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - adipokinetic hormone receptor activity
- adiponectin binding
- metal ion binding
- identical protein binding
- protein heterodimerization activity
- signaling receptor activity
| Cellular component | - integral component of membrane
- membrane
- intrinsic component of plasma membrane
- plasma membrane
| Biological process | - positive regulation of glucose import
- glucose homeostasis
- response to nutrient
- lipid metabolism
- female pregnancy
- adiponectin-activated signaling pathway
- fatty acid metabolic process
- vascular wound healing
- heart development
- negative regulation of cell growth
- fatty acid oxidation
- hormone-mediated signaling pathway
- regulation of fatty acid biosynthetic process
- positive regulation of cold-induced thermogenesis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000006831 ENSG00000285070 |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_024551 NM_001375363 NM_001375364 NM_001375365 |
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RefSeq (protein) | |
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NP_078827 NP_001362292 NP_001362293 NP_001362294 |
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Location (UCSC) | Chr 12: 1.69 – 1.79 Mb | Chr 6: 119.33 – 119.39 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.[6]
Structure
Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[5]
Function
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[5] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.[7]
Ligands
Agonists
Peptide
Non-peptide
Antagonists
Peptide
See also
References
- ^ a b c ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030168 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
- ^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
- ^ University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
- ^ a b c Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.
- ^ Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.
- ^ a b c d Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.
External links
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