Adrenal androgen-stimulating hormone
Adrenal androgen stimulating hormone (AASH), also known as cortical androgen stimulating hormone (CASH), is a hypothetical hormone which has been proposed to stimulate the adrenal glands to produce adrenal androgens such as dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4).[1][2] It is hypothesized to be involved in adrenarche and adrenopause.[1][2] The existence of this hormone is controversial and disputed and it has not been identified to date.[1] A number of other mechanisms and/or hormones may instead play the functional role of the so-called AASH.[1][2][3]
See also
- Adrenocorticotrophic hormone (ACTH)
References
- ^ a b c d Anderson DC (August 1980). "The adrenal androgen-stimulating hormone does not exist". Lancet. 2 (8192): 454–6. doi:10.1016/s0140-6736(80)91889-9. PMID 6106101.
- ^ a b c Alesci S, Bornstein SR (2001). "Intraadrenal mechanisms of DHEA regulation: a hypothesis for adrenopause". Exp Clin Endocrinol Diabetes. 109 (2): 75–82. doi:10.1055/s-2001-14826. PMID 11341302.
- ^ Parker LN (June 1991). "Control of adrenal androgen secretion". Endocrinol Metab Clin North Am. 20 (2): 401–21. doi:10.1016/S0889-8529(18)30275-5. PMID 1652437.
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