Alpha operon ribosome binding site
Alpha operon ribosome binding site | |
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![]() Predicted secondary structure and sequence conservation of Alpha_RBS | |
Identifiers | |
Symbol | Alpha_RBS |
Rfam | RF00140 |
Other data | |
RNA type | Cis-reg |
Domain(s) | Bacteria |
SO | SO:0000233 |
PDB structures | PDBe |
The alpha operon ribosome binding site in bacteria is surrounded by this complex pseudoknotted RNA structure. Translation of the mRNA produces 4 ribosomal protein products, one of which (S4) acts as a translational repressor by binding to the nested pseudoknot region. The mechanism of repression is thought to involve a conformational switch in the pseudoknot region and ribosome entrapment.[1]
References
- ^ Schlax PJ, Xavier KA, Gluick TC, Draper DE (October 2001). "Translational repression of the Escherichia coli alpha operon mRNA: importance of an mRNA conformational switch and a ternary entrapment complex". The Journal of Biological Chemistry. 276 (42): 38494–38501. doi:10.1074/jbc.M106934200. PMID 11504736.
External links
- Page for Alpha operon ribosome binding site at Rfam
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