Amanullin
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Other names 3-Isoleucine-alpha-amanitin | |
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Properties | |
Chemical formula | C39H54N10O12S |
Molar mass | 886.86 g/mol |
Appearance | Colorless, crystalline solid |
Solubility in water | Soluble |
Solubility in ethanol, methanol | Soluble |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references |
Chemical compound
Amanullin is a cyclic peptide. It is an amatoxin, all of which are found in several members of the mushroom genus Amanita. The oral LD50 of amanullin is approximately 20 mg/kg in mice; however, it is non-toxic in humans.
Toxicology
Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]
See also
References
- ^ Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.
External links
- Amatoxins REVISED Archived 2009-01-13 at the Wayback Machine
- Poisonous Mushrooms (German)
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Poisonous Amanita mushrooms
Amanita
Amanita |
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Amanitina
Lepidella (=Saproamanita) |
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Phalloideae |
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Roanokenses |
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