BRMS1

Protein-coding gene in the species Homo sapiens

BRMS1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2XUS, 4AUV

Identifiers

Aliases

BRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator

External IDs

OMIM: 606259; MGI: 2388804; HomoloGene: 32260; GeneCards: BRMS1; OMA:BRMS1 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.2	Start	66,337,333 bp^[1]
Band	11q13.2	End	66,345,125 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	5,091,382 bp^[2]
Band	19\|19 A	End	5,099,945 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

mucosa of transverse colon

monocyte

skin of leg

skin of abdomen

body of stomach

body of pancreas

sural nerve

minor salivary glands

mucosa of esophagus

Top expressed in

spermatid

blastocyst

yolk sac

morula

right kidney

granulocyte

embryo

embryo

neural layer of retina

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	histone deacetylase binding protein binding NF-kappaB binding histone deacetylase activity
Cellular component	cytoplasm Sin3-type complex nucleus nucleoplasm
Biological process	positive regulation of protein deacetylation positive regulation of anoikis negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity negative regulation of transcription by RNA polymerase II histone deacetylation regulation of transcription, DNA-templated transcription, DNA-templated apoptotic process regulation of apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


25855


107392

Ensembl


ENSG00000174744


ENSMUSG00000080268

UniProt


Q9HCU9


Q99N20

RefSeq (mRNA)


NM_015399 NM_001024957 NM_001024958


NM_134155 NM_001374047 NM_001374048

RefSeq (protein)


NP_001020128 NP_056214


NP_598916 NP_001360976 NP_001360977

Location (UCSC)

Chr 11: 66.34 – 66.35 Mb

Chr 19: 5.09 – 5.1 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.^[5]^[6]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.^[7] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174744 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000080268 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research. 60 (11): 2764–9. PMID 10850410.
^ ^a ^b "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
^ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

External links

Human BRMS1 genome location and BRMS1 gene details page in the UCSC Genome Browser.

Meehan WJ, Welch DR (2003). "Breast cancer metastasis suppressor 1: update". Clin. Exp. Metastasis. 20 (1): 45–50. doi:10.1023/A:1022542519586. PMID 12650606. S2CID 26142383.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Samant RS, Debies MT, Shevde LA, et al. (2002). "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)". Int. J. Cancer. 97 (1): 15–20. doi:10.1002/ijc.1569. PMID 11774238. S2CID 19747938.
Shevde LA, Samant RS, Goldberg SF, et al. (2002). "Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1". Exp. Cell Res. 273 (2): 229–39. doi:10.1006/excr.2001.5452. PMID 11822878.
Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. doi:10.1210/jc.2002-021093. PMID 12414911.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Meehan WJ, Samant RS, Hopper JE, et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription". J. Biol. Chem. 279 (2): 1562–9. doi:10.1074/jbc.M307969200. PMID 14581478.
Cicek M, Samant RS, Kinter M, et al. (2004). "Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells". Clin. Exp. Metastasis. 21 (2): 149–57. doi:10.1023/B:CLIN.0000024729.19084.f0. PMID 15168732. S2CID 19383717.
Nikolaev AY, Papanikolaou NA, Li M, et al. (2004). "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex". Biochem. Biophys. Res. Commun. 323 (4): 1216–22. doi:10.1016/j.bbrc.2004.08.227. PMID 15451426.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stark AM, Tongers K, Maass N, et al. (2005). "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases". J. Cancer Res. Clin. Oncol. 131 (3): 191–8. doi:10.1007/s00432-004-0629-9. PMID 15592684. S2CID 12411341.
DeWald DB, Torabinejad J, Samant RS, et al. (2005). "Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells". Cancer Res. 65 (3): 713–7. doi:10.1158/0008-5472.713.65.3. PMID 15705865. S2CID 24886361.
Cicek M, Fukuyama R, Welch DR, et al. (2005). "Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity". Cancer Res. 65 (9): 3586–95. doi:10.1158/0008-5472.CAN-04-3139. PMID 15867352.
Hurst DR, Mehta A, Moore BP, et al. (2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone". Biochem. Biophys. Res. Commun. 348 (4): 1429–35. doi:10.1016/j.bbrc.2006.08.005. PMC 1557677. PMID 16919237.
Samant RS, Clark DW, Fillmore RA, et al. (2007). "Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation". Mol. Cancer. 6: 6. doi:10.1186/1476-4598-6-6. PMC 1796551. PMID 17227585.
Rivera J, Megias D, Bravo J (2007). "Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1". J. Proteome Res. 6 (10): 4006–18. doi:10.1021/pr0703167. PMID 17854218.