C1QTNF1

Protein-coding gene in the species Homo sapiens
C1QTNF1
Identifiers
AliasesC1QTNF1, CTRP1, GIP, ZSIG37, C1q and tumor necrosis factor related protein 1, C1q and TNF related 1
External IDsOMIM: 610365; MGI: 1919254; HomoloGene: 10548; GeneCards: C1QTNF1; OMA:C1QTNF1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for C1QTNF1
Genomic location for C1QTNF1
Band17q25.3Start79,022,814 bp[1]
End79,049,788 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for C1QTNF1
Genomic location for C1QTNF1
Band11|11 E2Start118,319,029 bp[2]
End118,340,789 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right coronary artery

  • popliteal artery

  • tibial arteries

  • left coronary artery

  • right auricle

  • Descending thoracic aorta

  • ascending aorta

  • right lobe of thyroid gland

  • apex of heart

  • left lobe of thyroid gland
Top expressed in
  • decidua

  • gastrula

  • lumbar spinal ganglion

  • lip

  • esophagus

  • calvaria

  • ankle

  • ascending aorta

  • semi-lunar valve

  • aortic valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • collagen binding
Cellular component
  • extracellular region
  • collagen
  • integral component of plasma membrane
  • extracellular space
Biological process
  • positive regulation of cytosolic calcium ion concentration
  • negative regulation of platelet activation
  • protein heterotrimerization
  • regulation of glucose metabolic process
  • positive regulation of gene expression
  • positive regulation of protein kinase B signaling
  • positive regulation of aldosterone secretion
  • protein homooligomerization
  • negative regulation of platelet aggregation
  • positive regulation of MAPK cascade
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114897

56745

Ensembl

ENSG00000173918

ENSMUSG00000017446

UniProt

Q9BXJ1

Q9QXP7

RefSeq (mRNA)

NM_030968
NM_153372
NM_198593
NM_198594

NM_001204129
NM_001204130
NM_019959

RefSeq (protein)

NP_112230
NP_699203
NP_940995
NP_940996

NP_001191058
NP_001191059
NP_064343

Location (UCSC)Chr 17: 79.02 – 79.05 MbChr 11: 118.32 – 118.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complement C1q tumor necrosis factor-related protein 1 is a protein that in humans is encoded by the C1QTNF1 gene.[5][6]

Interactions

C1QTNF1 has been shown to interact with Arginine vasopressin receptor 2.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173918 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017446 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting protein". Regulatory Peptides. 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230. S2CID 30853177.
  6. ^ "Entrez Gene: C1QTNF1 C1q and tumor necrosis factor related protein 1".
  7. ^ Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (November 2002). "GIP, a G-protein-coupled receptor interacting protein". Regulatory Peptides. 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230. S2CID 30853177.

Further reading

  • Innamorati G, Bianchi E, Whang MI (June 2006). "An intracellular role for the C1q-globular domain". Cellular Signalling. 18 (6): 761–70. doi:10.1016/j.cellsig.2005.11.004. PMID 16386877.
  • Kim KY, Kim HY, Kim JH, Lee CH, Kim DH, Lee YH, Han SH, Lim JS, Cho DH, Lee MS, Yoon S, Kim KI, Yoon DY, Yang Y (July 2006). "Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue". FEBS Letters. 580 (16): 3953–60. doi:10.1016/j.febslet.2006.06.034. PMID 16806199. S2CID 84691242.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


  • v
  • t
  • e