CACUL1

Protein-coding gene in humans
CACUL1
Identifiers
AliasesCACUL1, C10orf46, CAC1, CDK2 associated cullin domain 1
External IDsMGI: 1926082; HomoloGene: 17821; GeneCards: CACUL1; OMA:CACUL1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for CACUL1
Genomic location for CACUL1
Band10q26.11Start118,674,167 bp[1]
End118,755,249 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for CACUL1
Genomic location for CACUL1
Band19|19 D3Start60,513,134 bp[2]
End60,569,463 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of arm

  • epithelium of nasopharynx

  • cardiac muscle tissue of right atrium

  • amniotic fluid

  • gingival epithelium

  • pancreatic epithelial cell

  • endothelial cell

  • myocardium of left ventricle

  • germinal epithelium

  • parietal pleura
Top expressed in
  • spermatid

  • seminiferous tubule

  • tail of embryo

  • arcuate nucleus

  • median eminence

  • extensor digitorum longus muscle

  • cingulate gyrus

  • plantaris muscle

  • stroma of bone marrow

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • protein kinase binding
  • ubiquitin protein ligase binding
  • ubiquitin protein ligase activity
Cellular component
  • cullin-RING ubiquitin ligase complex
Biological process
  • cell cycle
  • ubiquitin-dependent protein catabolic process
  • positive regulation of cell population proliferation
  • positive regulation of protein kinase activity
  • G1/S transition of mitotic cell cycle
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

143384

78832

Ensembl

ENSG00000151893

ENSMUSG00000033417

UniProt

Q86Y37

Q8R0X2

RefSeq (mRNA)

NM_153810

NM_001172096
NM_001172097
NM_030197

RefSeq (protein)

NP_722517

NP_001165567
NP_001165568
NP_084473

Location (UCSC)Chr 10: 118.67 – 118.76 MbChr 19: 60.51 – 60.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CDK2 associated cullin domain 1 is a protein that in humans is encoded by the CACUL1 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151893 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033417 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CDK2 associated cullin domain 1". Retrieved 2018-01-05.

Further reading

  • Kong Y, Nan K, Yin Y (2009). "Identification and characterization of CAC1 as a novel CDK2-associated cullin". Cell Cycle. 8 (21): 3552–61. doi:10.4161/cc.8.21.9955. PMID 19829063.
  • Kong Y, Bai PS, Sun H, Nan KJ (2012). "Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients". J. Mol. Neurosci. 47 (2): 207–18. doi:10.1007/s12031-012-9717-5. PMID 22415352. S2CID 14719772.
  • Kong Y, Bai PS, Sun H, Nan KJ, Chen NZ, Qi XG (2012). "The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer". Int. J. Biochem. Cell Biol. 44 (12): 2321–32. doi:10.1016/j.biocel.2012.08.006. PMID 22903020.
  • Moon M, Um SJ, Kim EJ (2012). "CAC1 negatively regulates RARα activity through cooperation with HDAC". Biochem. Biophys. Res. Commun. 427 (1): 41–6. doi:10.1016/j.bbrc.2012.08.142. PMID 22982681.
  • Kim J, Park UH, Moon M, Um SJ, Kim EJ (2013). "Negative regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1". FEBS Lett. 587 (1): 17–22. doi:10.1016/j.febslet.2012.10.054. PMID 23178685. S2CID 207659623.
  • Zheng Q, Zhao LY, Kong Y, Nan KJ, Yao Y, Liao ZJ (2013). "CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line". World J Surg Oncol. 11: 5. doi:10.1186/1477-7819-11-5. PMC 3585504. PMID 23311997.
  • Chen TJ, Gao F, Yang T, Thakur A, Ren H, Li Y, Zhang S, Wang T, Chen MW (2013). "CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells". Biochem. Biophys. Res. Commun. 437 (1): 108–13. doi:10.1016/j.bbrc.2013.06.048. PMID 23806693.
  • Kong Y, Ma LQ, Bai PS, Da R, Sun H, Qi XG, Ma JQ, Zhao RM, Chen NZ, Nan KJ (2013). "Helicobacter pylori promotes invasion and metastasis of gastric cancer cells through activation of AP-1 and up-regulation of CACUL1". Int. J. Biochem. Cell Biol. 45 (11): 2666–78. doi:10.1016/j.biocel.2013.08.015. PMID 24004834.
  • Ma HL, Wen XP, Zhang XZ, Wang XL, Zhao DL, Che SM, Dang CX (2015). "miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1)". Cell. Mol. Biol. (Noisy-le-grand). 61 (4): 56–62. PMID 26314198.


  • v
  • t
  • e