CACYBP

Protein-coding gene in humans
CACYBP
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1X5M, 2A25, 2A26

Identifiers
AliasesCACYBP, GIG5, S100A6BP, SIP, PNAS-107, calcyclin binding protein
External IDsOMIM: 606186; MGI: 1270839; HomoloGene: 7649; GeneCards: CACYBP; OMA:CACYBP - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CACYBP
Genomic location for CACYBP
Band1q25.1Start174,999,163 bp[1]
End175,012,027 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CACYBP
Genomic location for CACYBP
Band1|1 H2.1Start160,029,937 bp[2]
End160,040,445 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • pons

  • postcentral gyrus

  • entorhinal cortex

  • superior frontal gyrus

  • middle temporal gyrus

  • Brodmann area 46

  • Brodmann area 23

  • orbitofrontal cortex

  • ventricular zone
Top expressed in
  • primitive streak

  • abdominal wall

  • tail of embryo

  • mandibular prominence

  • genital tubercle

  • maxillary prominence

  • somite

  • yolk sac

  • arcuate nucleus

  • dorsomedial hypothalamic nucleus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein homodimerization activity
  • protein domain specific binding
  • ubiquitin protein ligase binding
  • tubulin binding
  • S100 protein binding
Cellular component
  • nuclear envelope lumen
  • extracellular exosome
  • beta-catenin destruction complex
  • nucleus
  • nucleoplasm
  • neuron projection
  • cell body
  • cytoplasm
  • cytosol
  • SCF ubiquitin ligase complex
Biological process
  • cardiac muscle cell differentiation
  • positive regulation of DNA replication
  • human ageing
  • negative regulation of cell death
  • cellular response to calcium ion
  • heart development
  • response to growth hormone
  • cellular response to leukemia inhibitory factor
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27101

12301

Ensembl

ENSG00000116161

ENSMUSG00000014226

UniProt

Q9HB71

Q9CXW3

RefSeq (mRNA)

NM_014412
NM_001007214

NM_009786

RefSeq (protein)

NP_001007215
NP_055227

NP_033916

Location (UCSC)Chr 1: 175 – 175.01 MbChr 1: 160.03 – 160.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.[5][6][7]

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]

Protein Interactions

CACYBP has been shown to interact with SKP1A[8] and SIAH1.[5]

The CacyBP/SIP complex instead, is known to be a part of stress respons, since it interacts with chaperone HSP90.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116161 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014226 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Molecular Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
  6. ^ Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (January 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". The Journal of Biological Chemistry. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.
  7. ^ a b "Entrez Gene: CACYBP calcyclin binding protein".
  8. ^ Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Molecular Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
  9. ^ Filipek, Anna; Leśniak, Wiesława (2018-12-29). "Aktualny pogląd na komórkową funkcję S100A6 i jego ligandów, CacyBP/SIP i Sgt1". Postępy Biochemii (in Polish). 64 (3): 242–252. doi:10.18388/pb.2018_136. ISSN 0032-5422. PMID 30656909.

Further reading

  • Filipek A, Jastrzebska B, Nowotny M, Kwiatkowska K, Hetman M, Surmacz L, et al. (June 2002). "Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells". The Journal of Biological Chemistry. 277 (23): 21103–9. doi:10.1074/jbc.M111010200. PMID 11927578.
  • Liu WX, Wu J, Zhao Z, Zhou Y, Peng XZ, Yuan JG, Qiang BQ (March 2002). "[Cloning and expression of human calcyclin binding protein (hCacyBP) gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (2): 181–6. PMID 12006993.
  • Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (August 2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". The Journal of Biological Chemistry. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.
  • Wu J, Tan X, Peng X, Yuan J, Qiang B (July 2003). "Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells". Journal of Biochemistry and Molecular Biology. 36 (4): 354–8. doi:10.5483/bmbrep.2003.36.4.354. PMID 12895292.
  • Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, et al. (October 2005). "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex". The Journal of Biological Chemistry. 280 (40): 34278–87. doi:10.1074/jbc.M506707200. PMID 16085652.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Sun S, Ning X, Liu J, Liu L, Chen Y, Han S, et al. (May 2007). "Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma". Biochemical and Biophysical Research Communications. 356 (4): 864–71. doi:10.1016/j.bbrc.2007.03.080. PMID 17400182.
  • v
  • t
  • e
  • 1x5m: Solution structure of the core domain of calcyclin binding protein; siah-interacting protein (SIP)
    1x5m: Solution structure of the core domain of calcyclin binding protein; siah-interacting protein (SIP)
  • 2a26: Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein
    2a26: Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein


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