CALY

Protein-coding gene in humans
CALY
Identifiers
AliasesCALY, DRD1IP, NSG3, calcyon neuron specific vesicular protein
External IDsOMIM: 604647; MGI: 1915816; HomoloGene: 9256; GeneCards: CALY; OMA:CALY - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for CALY
Genomic location for CALY
Band10q26.3Start133,324,072 bp[1]
End133,336,935 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CALY
Genomic location for CALY
Band7|7 F4Start139,649,793 bp[2]
End139,662,461 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nucleus accumbens

  • right frontal lobe

  • hypothalamus

  • pituitary gland

  • anterior cingulate cortex

  • caudate nucleus

  • prefrontal cortex

  • anterior pituitary

  • right hemisphere of cerebellum

  • amygdala
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • superior frontal gyrus

  • hippocampus proper

  • nucleus of stria terminalis

  • arcuate nucleus

  • central gray substance of midbrain

  • ventromedial nucleus

  • paraventricular nucleus of hypothalamus

  • dorsomedial hypothalamic nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • clathrin light chain binding
  • protein-containing complex binding
  • cargo receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • cytoplasmic vesicle membrane
  • cytoplasmic vesicle
  • membrane
  • endosome
  • postsynaptic endocytic zone
  • glutamatergic synapse
Biological process
  • clathrin coat assembly
  • dopamine receptor signaling pathway
  • positive regulation of endocytosis
  • endocytosis
  • endosomal transport
  • postsynaptic neurotransmitter receptor internalization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50632

68566

Ensembl

ENSG00000130643

ENSMUSG00000025468

UniProt

Q9NYX4

Q9DCA7

RefSeq (mRNA)

NM_015722
NM_001321617

NM_001190385
NM_001190386
NM_026769

RefSeq (protein)

NP_001308546
NP_056537

NP_001177314
NP_001177315
NP_081045

Location (UCSC)Chr 10: 133.32 – 133.34 MbChr 7: 139.65 – 139.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuron-specific vesicular protein calcyon is a protein that in humans is encoded by the CALY gene.[5][6] Its alternative name is Calcyon.

Function

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with dopamine receptor D1 and may interact with other DA receptor subtypes and/or GPCRs.[6]

Interactions

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130643 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025468 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Heijtz RD, Alexeyenko A, Castellanos FX (July 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD". Behavioral and Brain Functions. 3 (1): 33. doi:10.1186/1744-9081-3-33. PMC 1949817. PMID 17623072.
  6. ^ a b "CALY calcyon neuron specific vesicular protein [ Homo sapiens (human) ]".
  7. ^ Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, et al. (March 2021). "Hevin-calcyon interaction promotes synaptic reorganization after brain injury". Cell Death and Differentiation. 28 (9): 2571–2588. doi:10.1038/s41418-021-00772-5. PMC 8408247. PMID 33753902.

Further reading

  • Milligan G, White JH (October 2001). "Protein-protein interactions at G-protein-coupled receptors". Trends in Pharmacological Sciences. 22 (10): 513–8. doi:10.1016/S0165-6147(00)01801-0. PMID 11583808.
  • Ali MK, Bergson C (December 2003). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane". The Journal of Biological Chemistry. 278 (51): 51654–63. doi:10.1074/jbc.M305803200. PMID 14534309.
  • Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J (February 2004). "CALCYON gene variation, schizophrenia, and cocaine dependence". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 125B (1): 25–30. doi:10.1002/ajmg.b.20092. PMID 14755439. S2CID 24881261.
  • Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, Malone M, Tannock R, Schachar R, Kennedy JL, Barr CL (December 2005). "Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder". Molecular Psychiatry. 10 (12): 1117–25. doi:10.1038/sj.mp.4001737. PMID 16172615. S2CID 25367235.
  • Xiao J, Dai R, Negyessy L, Bergson C (June 2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis". The Journal of Biological Chemistry. 281 (22): 15182–93. doi:10.1074/jbc.M600265200. PMID 16595675.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Kruusmägi M, Zelenin S, Brismar H, Scott L (October 2007). "Intracellular dynamics of calcyon, a neuron-specific vesicular protein". NeuroReport. 18 (15): 1547–51. doi:10.1097/WNR.0b013e3282f03f51. PMID 17885599. S2CID 24544827.


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