CARMIL1

Protein found in humans

CARMIL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3LK2, 3LK3

Identifiers
AliasesCARMIL1, CARMIL, CARMIL1a, LRRC16, dJ501N12.1, dJ501N12.5, LRRC16A, leucine rich repeat containing 16A, capping protein regulator and myosin 1 linker 1
External IDsOMIM: 609593; MGI: 1915982; HomoloGene: 9757; GeneCards: CARMIL1; OMA:CARMIL1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CARMIL1
Genomic location for CARMIL1
Band6p22.2Start25,279,078 bp[1]
End25,620,530 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for CARMIL1
Genomic location for CARMIL1
Band13|13 A3.1Start24,196,327 bp[2]
End24,464,778 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • Achilles tendon

  • mucosa of transverse colon

  • left coronary artery

  • right hemisphere of cerebellum

  • thoracic aorta

  • Descending thoracic aorta

  • ascending aorta

  • testicle
Top expressed in
  • zygote

  • secondary oocyte

  • molar

  • saccule

  • primary oocyte

  • otic vesicle

  • spermatid

  • vestibular sensory epithelium

  • otic placode

  • medullary collecting duct
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein-containing complex binding
  • protein binding
Cellular component
  • filamentous actin
  • cell projection
  • membrane
  • plasma membrane
  • macropinosome
  • cell leading edge
  • extracellular exosome
  • cytoskeleton
  • nucleus
  • lamellipodium
  • cytoplasm
  • cytosol
  • nuclear speck
Biological process
  • barbed-end actin filament uncapping
  • positive regulation of lamellipodium organization
  • negative regulation of barbed-end actin filament capping
  • positive regulation of actin filament polymerization
  • ruffle organization
  • actin filament organization
  • positive regulation of cell migration
  • actin filament network formation
  • blood coagulation
  • positive regulation of substrate adhesion-dependent cell spreading
  • macropinocytosis
  • urate metabolic process
  • cell migration
  • positive regulation of stress fiber assembly
  • lamellipodium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55604

68732

Ensembl

ENSG00000079691

ENSMUSG00000021338

UniProt

Q5VZK9

Q6EDY6

RefSeq (mRNA)

NM_001173977
NM_017640

NM_026825
NM_177807
NM_001311122
NM_001384122

RefSeq (protein)

NP_001167448
NP_060110

NP_001298051
NP_081101
NP_001371051

Location (UCSC)Chr 6: 25.28 – 25.62 MbChr 13: 24.2 – 24.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CARMIL1 is a protein that in humans is encoded by the CARMIL1 gene.[5] The gene is also known as LRRC16, LRRC16A, CARMIL, or CARMIL1a.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079691 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021338 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "capping protein regulator and myosin 1 linker 1". Retrieved 2020-11-09.

Further reading

  • Yang C, Pring M, Wear MA, Huang M, Cooper JA, Svitkina TM, et al. (August 2005). "Mammalian CARMIL inhibits actin filament capping by capping protein". Developmental Cell. 9 (2): 209–221. doi:10.1016/j.devcel.2005.06.008. PMC 2628720. PMID 16054028.
  • Liang Y, Niederstrasser H, Edwards M, Jackson CE, Cooper JA (December 2009). "Distinct roles for CARMIL isoforms in cell migration". Molecular Biology of the Cell. 20 (24): 5290–5305. doi:10.1091/mbc.E08-10-1071. PMC 2793302. PMID 19846667.
  • Gunjaca G, Boban M, Pehlić M, Zemunik T, Budimir D, Kolcić I, et al. (February 2010). "Predictive value of 8 genetic loci for serum uric acid concentration". Croatian Medical Journal. 51 (1): 23–31. doi:10.3325/cmj.2010.51.23. PMC 2829178. PMID 20162742.
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