CCDC28B

Protein found in humans
CCDC28B
Identifiers
AliasesCCDC28B, coiled-coil domain containing 28B
External IDsOMIM: 610162; MGI: 1913514; HomoloGene: 11509; GeneCards: CCDC28B; OMA:CCDC28B - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CCDC28B
Genomic location for CCDC28B
Band1p35.2Start32,200,595 bp[1]
End32,205,453 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for CCDC28B
Genomic location for CCDC28B
Band4|4 D2.2Start129,513,067 bp[2]
End129,517,740 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • gastrocnemius muscle

  • triceps brachii muscle

  • right uterine tube

  • Skeletal muscle tissue of rectus abdominis

  • right testis

  • left testis

  • vastus lateralis muscle

  • anterior pituitary

  • apex of heart
Top expressed in
  • neural layer of retina

  • cerebellar cortex

  • lobe of cerebellum

  • cerebellar vermis

  • lip

  • neural tube

  • dentate gyrus of hippocampal formation granule cell

  • sternocleidomastoid muscle

  • temporal muscle

  • granulocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • centrosome
  • cytoskeleton
  • microtubule organizing center
Biological process
  • cell projection organization
  • cilium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79140

66264

Ensembl

ENSG00000160050

ENSMUSG00000028795

UniProt

Q9BUN5

Q8CEG5

RefSeq (mRNA)

NM_001301011
NM_024296

NM_025455

RefSeq (protein)

NP_001287940
NP_077272

NP_079731

Location (UCSC)Chr 1: 32.2 – 32.21 MbChr 4: 129.51 – 129.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coiled-coil domain-containing protein 28B is a protein that in humans is encoded by the CCDC28B gene.[5][6]

The product of this gene localizes to centrosomes and basal bodies. It interacts and colocalizes with several proteins associated with Bardet–Biedl syndrome (BBS).[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160050 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028795 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Badano JL, Leitch CC, Ansley SJ, May-Simera H, Lawson S, Lewis RA, Beales PL, Dietz HC, Fisher S, Katsanis N (Jan 2006). "Dissection of epistasis in oligogenic Bardet-Biedl syndrome". Nature. 439 (7074): 326–30. Bibcode:2006Natur.439..326B. doi:10.1038/nature04370. PMID 16327777. S2CID 4355521.
  6. ^ a b "Entrez Gene: CCDC28B coiled-coil domain containing 28B".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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