CCDC85B

Protein-coding gene in humans

CCDC85B
Identifiers
AliasesCCDC85B, DIPA, coiled-coil domain containing 85B
External IDsOMIM: 605360; MGI: 2147607; HomoloGene: 4989; GeneCards: CCDC85B; OMA:CCDC85B - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CCDC85B
Genomic location for CCDC85B
Band11q13.1Start65,890,673 bp[1]
End65,891,635 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for CCDC85B
Genomic location for CCDC85B
Band19|19 AStart5,503,208 bp[2]
End5,507,922 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amygdala

  • Brodmann area 9

  • right frontal lobe

  • nucleus accumbens

  • putamen

  • apex of heart

  • caudate nucleus

  • Region I of hippocampus proper

  • cingulate gyrus

  • anterior cingulate cortex
Top expressed in
  • anterior horn of spinal cord

  • facial motor nucleus

  • endothelial cell of lymphatic vessel

  • epithelium of lens

  • otolith organ

  • utricle

  • prefrontal cortex

  • hippocampus proper

  • primary motor cortex

  • cingulate gyrus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • centrosome
  • cytoskeleton
  • nucleus
  • microtubule organizing center
Biological process
  • regulation of growth
  • cell differentiation
  • negative regulation of fat cell differentiation
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • negative regulation of cell growth
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11007

240514

Ensembl

ENSG00000175602

ENSMUSG00000095098

UniProt

Q15834

Q6PDY0

RefSeq (mRNA)

NM_006848

NM_001243307
NM_198616

RefSeq (protein)

NP_006839

NP_001230236
NP_941018

Location (UCSC)Chr 11: 65.89 – 65.89 MbChr 19: 5.5 – 5.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.[5][6][7]

Function

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro.[7]

Interactions

CCDC85B has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175602 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000095098 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brazas R, Ganem D (Oct 1996). "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution". Science. 274 (5284): 90–4. Bibcode:1996Sci...274...90B. doi:10.1126/science.274.5284.90. PMID 8810253. S2CID 20743492.
  6. ^ Bezy O, Elabd C, Cochet O, Petersen RK, Kristiansen K, Dani C, et al. (Mar 2005). "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation". The Journal of Biological Chemistry. 280 (12): 11432–8. doi:10.1074/jbc.M411741200. PMID 15644333.
  7. ^ a b "Entrez Gene: CCDC85B coiled-coil domain containing 85B".
  8. ^ a b c d Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Robertson HD (Oct 1996). "How did replicating and coding RNAs first get together?". Science. 274 (5284): 66–7. Bibcode:1996Sci...274...66R. doi:10.1126/science.274.5284.66. PMID 8848724. S2CID 37715470.
  • Long M, de Souza SJ, Gilbert W (May 1997). "Delta-interacting protein A and the origin of hepatitis delta antigen". Science. 276 (5313): 824–5. doi:10.1126/science.276.5313.824. PMID 9115212.
  • Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, et al. (Feb 2005). "C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage". Cell Death and Differentiation. 12 (2): 153–61. doi:10.1038/sj.cdd.4401539. PMID 15605074.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843.
  • v
  • t
  • e