CCNL1

Protein-coding gene in the species Homo sapiens
CCNL1
Identifiers
AliasesCCNL1, ANIA6A, PRO1073, ania-6a, BM-001, cyclin L1
External IDsOMIM: 613384; MGI: 1922664; HomoloGene: 10541; GeneCards: CCNL1; OMA:CCNL1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CCNL1
Genomic location for CCNL1
Band3q25.31Start157,146,508 bp[1]
End157,160,760 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CCNL1
Genomic location for CCNL1
Band3|3 E1Start65,853,572 bp[2]
End65,865,670 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastric mucosa

  • granulocyte

  • left uterine tube

  • monocyte

  • left ovary

  • right ovary

  • right lung

  • skin of abdomen

  • left lobe of thyroid gland

  • anterior pituitary
Top expressed in
  • granulocyte

  • saccule

  • Rostral migratory stream

  • tail of embryo

  • crypt of lieberkuhn of small intestine

  • pineal gland

  • otic vesicle

  • thymus

  • otic placode

  • genital tubercle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cyclin-dependent protein serine/threonine kinase regulator activity
  • protein binding
Cellular component
  • nuclear speck
  • cyclin-dependent protein kinase holoenzyme complex
  • nucleoplasm
  • nucleus
Biological process
  • positive regulation of phosphorylation of RNA polymerase II C-terminal domain
  • RNA processing
  • regulation of cyclin-dependent protein serine/threonine kinase activity
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57018

56706

Ensembl

ENSG00000163660

ENSMUSG00000027829

UniProt

Q9UK58

Q52KE7

RefSeq (mRNA)

NM_001308185
NM_020307

NM_001025442
NM_001025443
NM_019937
NM_001355432
NM_001355433

RefSeq (protein)

NP_001295114
NP_064703

NP_064321
NP_001342361
NP_001342362

Location (UCSC)Chr 3: 157.15 – 157.16 MbChr 3: 65.85 – 65.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163660 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027829 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (Jul 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". J Biol Chem. 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906.
  6. ^ "Entrez Gene: CCNL1 cyclin L1".

Further reading

  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Berke JD, Sgambato V, Zhu PP, et al. (2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron. 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997. S2CID 14486999.
  • Redon R, Hussenet T, Bour G, et al. (2002). "Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer". Cancer Res. 62 (21): 6211–7. PMID 12414649.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sticht C, Hofele C, Flechtenmacher C, et al. (2005). "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)". Br. J. Cancer. 92 (4): 770–4. doi:10.1038/sj.bjc.6602400. PMC 2361871. PMID 15700036.
  • Muller D, Millon R, Théobald S, et al. (2006). "Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma". Br. J. Cancer. 94 (7): 1041–4. doi:10.1038/sj.bjc.6603036. PMC 2361229. PMID 16598186.
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