CENTB1

Protein-coding gene in the species Homo sapiens

ACAP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3JUE, 3T9K, 4CKG, 4CKH, 4F1P, 4NSW

Identifiers
AliasesACAP1, CENTB1, ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
External IDsOMIM: 607763; MGI: 2388270; HomoloGene: 22835; GeneCards: ACAP1; OMA:ACAP1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ACAP1
Genomic location for ACAP1
Band17p13.1Start7,336,529 bp[1]
End7,351,477 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for ACAP1
Genomic location for ACAP1
Band11|11 B3Start69,772,393 bp[2]
End69,786,365 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • blood

  • lymph node

  • spleen

  • bone marrow cells

  • left testis

  • right testis

  • appendix

  • nucleus accumbens

  • pituitary gland
Top expressed in
  • granulocyte

  • thymus

  • blood

  • lymph node

  • mesenteric lymph nodes

  • spleen

  • pharynx

  • bone marrow

  • subcutaneous adipose tissue

  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • GTPase activator activity
Cellular component
  • endosome
  • recycling endosome membrane
  • membrane
  • intracellular membrane-bounded organelle
Biological process
  • protein transport
  • positive regulation of GTPase activity
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9744

216859

Ensembl

ENSG00000072818
ENSG00000288169

ENSMUSG00000001588

UniProt

Q15027

Q8K2H4

RefSeq (mRNA)

NM_014716

NM_153788

RefSeq (protein)

NP_055531

NP_722483

Location (UCSC)Chr 17: 7.34 – 7.35 MbChr 11: 69.77 – 69.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ACAP1 gene.[5][6][7]

References

  1. ^ a b c ENSG00000288169 GRCh38: Ensembl release 89: ENSG00000072818, ENSG00000288169 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001588 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.
  6. ^ Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579. PMID 11062263.
  7. ^ "Entrez Gene: CENTB1 centaurin, beta 1".

Further reading

  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Dai J, Li J, Bos E, et al. (2004). "ACAP1 promotes endocytic recycling by recognizing recycling sorting signals". Dev. Cell. 7 (5): 771–6. doi:10.1016/j.devcel.2004.10.002. PMID 15525538.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
  • Yamamoto-Furusho JK, Barnich N, Xavier R, et al. (2007). "Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation". J. Biol. Chem. 281 (47): 36060–70. doi:10.1074/jbc.M602383200. PMID 17005562.
  • Shinozaki-Narikawa N, Kodama T, Shibasaki Y (2007). "Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation". Traffic. 7 (11): 1539–50. doi:10.1111/j.1600-0854.2006.00480.x. PMID 17010122. S2CID 39282089.
  • Li J, Peters PJ, Bai M, et al. (2007). "An ACAP1-containing clathrin coat complex for endocytic recycling". J. Cell Biol. 178 (3): 453–64. doi:10.1083/jcb.200608033. PMC 2064835. PMID 17664335.


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