CENTB2

Protein-coding gene in the species Homo sapiens
ACAP2
Identifiers
AliasesACAP2, CENTB2, CNT-B2, ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
External IDsOMIM: 607766; MGI: 1925868; HomoloGene: 8182; GeneCards: ACAP2; OMA:ACAP2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ACAP2
Genomic location for ACAP2
Band3q29Start195,274,745 bp[1]
End195,443,044 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for ACAP2
Genomic location for ACAP2
Band16|16 B2Start30,911,230 bp[2]
End31,020,063 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of nasopharynx

  • bone marrow cells

  • superficial temporal artery

  • trabecular bone

  • human penis

  • Achilles tendon

  • palpebral conjunctiva

  • jejunal mucosa

  • oral cavity

  • mucosa of paranasal sinus
Top expressed in
  • stroma of bone marrow

  • superior cervical ganglion

  • left lung lobe

  • transitional epithelium of urinary bladder

  • otic vesicle

  • visual cortex

  • primary visual cortex

  • conjunctival fornix

  • hand

  • skin of external ear
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • GTPase activator activity
  • phosphatidylinositol-3,5-bisphosphate binding
Cellular component
  • endosome
  • endosome membrane
  • membrane
Biological process
  • protein localization to endosome
  • positive regulation of GTPase activity
  • cellular response to nerve growth factor stimulus
  • endocytic recycling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23527

78618

Ensembl

ENSG00000114331

ENSMUSG00000049076

UniProt

Q15057

Q6ZQK5

RefSeq (mRNA)

NM_012287

NM_030138

RefSeq (protein)

NP_036419

NP_084414

Location (UCSC)Chr 3: 195.27 – 195.44 MbChr 16: 30.91 – 31.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ACAP2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114331 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049076 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.
  6. ^ Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579. PMID 11062263.
  7. ^ "Entrez Gene: CENTB2 centaurin, beta 2".

Further reading

  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.


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