CENTD1

Protein-coding gene in the species Homo sapiens
ARAP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1X40, 2COD

Identifiers
AliasesARAP2, CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
External IDsOMIM: 606645; MGI: 2684416; HomoloGene: 9064; GeneCards: ARAP2; OMA:ARAP2 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ARAP2
Genomic location for ARAP2
Band4p14Start35,948,221 bp[1]
End36,244,514 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for ARAP2
Genomic location for ARAP2
Band5|5 C3.1Start62,759,788 bp[2]
End62,923,502 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • secondary oocyte

  • corpus callosum

  • gingival epithelium

  • optic nerve

  • dorsal motor nucleus of vagus nerve

  • amniotic fluid

  • internal globus pallidus

  • middle temporal gyrus

  • Brodmann area 23
Top expressed in
  • secondary oocyte

  • medial geniculate nucleus

  • zygote

  • hair follicle

  • subdivision of hippocampus

  • Region I of hippocampus proper

  • primary motor cortex

  • lateral geniculate nucleus

  • inferior colliculus

  • piriform cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • GTPase activator activity
  • phosphatidylinositol-3,4,5-trisphosphate binding
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • positive regulation of GTPase activity
  • regulation of small GTPase mediated signal transduction
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116984

212285

Ensembl

ENSG00000047365

ENSMUSG00000037999

UniProt

Q8WZ64

Q8BZ05

RefSeq (mRNA)

NM_015230
NM_139182

NM_178407

RefSeq (protein)

NP_056045

n/a

Location (UCSC)Chr 4: 35.95 – 36.24 MbChr 5: 62.76 – 62.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.[5]

Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000047365 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037999 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CENTD1 centaurin, delta 1".

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Yoon HY, Miura K, Cuthbert EJ, Davis KK, Ahvazi B, Casanova JE, Randazzo PA (November 2006). "ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP". Journal of Cell Science. 119 (Pt 22): 4650–66. doi:10.1242/jcs.03237. PMID 17077126.
  • Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, Resau J, Zheng Y, Randazzo PA (January 2002). "ARAP1: a point of convergence for Arf and Rho signaling". Molecular Cell. 9 (1): 109–19. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
  • Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (January 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Molecular Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  • v
  • t
  • e
  • 1x40: Solution structure of the SAM domain of human ARAP2
    1x40: Solution structure of the SAM domain of human ARAP2
  • 2cod: The deposition and citation title is: Solution structure of the N-terminal PH domain of ARAP2 protein from human
    2cod: The deposition and citation title is: Solution structure of the N-terminal PH domain of ARAP2 protein from human
Stub icon

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e