CENTD2

Protein-coding gene in the species Homo sapiens
ARAP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4X1V

Identifiers
AliasesARAP1, CENTD2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, cnt-d2
External IDsOMIM: 606646; MGI: 1916960; HomoloGene: 12326; GeneCards: ARAP1; OMA:ARAP1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ARAP1
Genomic location for ARAP1
Band11q13.4Start72,685,069 bp[1]
End72,793,599 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ARAP1
Genomic location for ARAP1
Band7|7 E2Start100,997,274 bp[2]
End101,061,793 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • right uterine tube

  • upper lobe of left lung

  • right lung

  • spleen

  • right adrenal cortex

  • left adrenal cortex

  • anterior pituitary

  • right lobe of thyroid gland
Top expressed in
  • granulocyte

  • lip

  • gastrula

  • stroma of bone marrow

  • efferent ductule

  • tibiofemoral joint

  • thymus

  • lumbar spinal ganglion

  • uterus

  • spleen
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • protein binding
  • GTPase activator activity
  • phosphatidylinositol-3,4,5-trisphosphate binding
  • type 1 angiotensin receptor binding
Cellular component
  • cytoplasm
  • Golgi apparatus
  • membrane
  • Golgi cisterna membrane
  • trans-Golgi network
  • cytoplasmic vesicle
  • nucleoplasm
  • cytosol
  • plasma membrane
  • intracellular membrane-bounded organelle
Biological process
  • actin filament reorganization involved in cell cycle
  • regulation of cell shape
  • negative regulation of stress fiber assembly
  • regulation of small GTPase mediated signal transduction
  • positive regulation of filopodium assembly
  • signal transduction
  • positive regulation of receptor recycling
  • positive regulation of epidermal growth factor receptor signaling pathway
  • positive regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116985

69710

Ensembl

ENSG00000186635

ENSMUSG00000032812

UniProt

Q96P48

Q4LDD4

RefSeq (mRNA)

NM_015242
NM_001040118
NM_001135190
NM_001369489

NM_001040111
NM_001040112
NM_027180
NM_198096

RefSeq (protein)

NP_001035207
NP_001128662
NP_056057
NP_001356418

NP_001035200
NP_001035201
NP_081456
NP_932764
NP_001394730

NP_001394732

Location (UCSC)Chr 11: 72.69 – 72.79 MbChr 7: 101 – 101.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.[5]

Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186635 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032812 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CENTD2 centaurin, delta 2".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (January 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Molecular Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
  • Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, Resau J, Zheng Y, Randazzo PA (January 2002). "ARAP1: a point of convergence for Arf and Rho signaling". Molecular Cell. 9 (1): 109–19. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
  • Ahn J, Chung KS, Kim DU, Won M, Kim L, Kim KS, Nam M, Choi SJ, Kim HC, Yoon M, Chae SK, Hoe KL (November 2004). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". Journal of Biochemistry and Molecular Biology. 37 (6): 741–8. doi:10.5483/bmbrep.2004.37.6.741. PMID 15607035.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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