CENTG1
Protein-coding gene in the species Homo sapiens
AGAP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | AGAP2, CENTG1, GGAP2, PIKE, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605476; MGI: 3580016; HomoloGene: 86815; GeneCards: AGAP2; OMA:AGAP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.[5]
Interactions
CENTG1 has been shown to interact with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135439 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025422 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: CENTG1 centaurin, gamma 1".
- ^ a b Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977. S2CID 16610638.
- ^ Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.
External links
- Human AGAP2 genome location and AGAP2 gene details page in the UCSC Genome Browser.
Further reading
- Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
- Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
- Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977. S2CID 16610638.
- Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH (2002). "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE". Nature. 415 (6871): 541–4. doi:10.1038/415541a. PMID 11823862. S2CID 4371421.
- Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA (2003). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". J. Biol. Chem. 277 (50): 48965–75. doi:10.1074/jbc.M202969200. PMID 12388557.
- Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–88. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
- Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.
- Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K (2004). "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion". J. Biol. Chem. 279 (16): 16441–51. doi:10.1074/jbc.M312175200. PMID 14761976.
- Ahn JY, Hu Y, Kroll TG, Allard P, Ye K (2004). "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6993–8. Bibcode:2004PNAS..101.6993A. doi:10.1073/pnas.0400921101. PMC 406454. PMID 15118108.
- Nie Z, Fei J, Premont RT, Randazzo PA (2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3". J. Cell Sci. 118 (Pt 15): 3555–66. doi:10.1242/jcs.02486. PMID 16079295.
- Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas". Neuropathol. Appl. Neurobiol. 31 (5): 486–90. doi:10.1111/j.1365-2990.2005.00660.x. PMID 16150119. S2CID 21766234.
- Hu Y, Liu Z, Ye K (2006). "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853–8. doi:10.1073/pnas.0507365102. PMC 1283830. PMID 16263930.
- Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival". Cell Death Differ. 14 (2): 368–77. doi:10.1038/sj.cdd.4402011. PMID 16841086.
- Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA (2007). "The centaurin gamma-1 GTPase-like domain functions as an NTPase". Biochem. J. 401 (3): 679–88. doi:10.1042/BJ20060555. PMC 1770848. PMID 17037982.
- Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A". J. Virol. 81 (5): 2340–8. doi:10.1128/JVI.01310-06. PMC 1865929. PMID 17151107.
- Liu X, Hu Y, Hao C, Rempel SA, Ye K (2007). "PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion". Oncogene. 26 (34): 4918–27. doi:10.1038/sj.onc.1210290. PMID 17297440. S2CID 1156814.
- Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2". Traffic. 8 (6): 661–72. doi:10.1111/j.1600-0854.2007.00561.x. PMID 17461797. S2CID 28218061.
- v
- t
- e
PDB gallery
- 2bmj: GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
- 2iwr: GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
![]() | This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e