CENTG3

Protein-coding gene in the species Homo sapiens
AGAP3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3IHW

Identifiers
AliasesAGAP3, AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
External IDsOMIM: 616813; MGI: 2183446; HomoloGene: 23742; GeneCards: AGAP3; OMA:AGAP3 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for AGAP3
Genomic location for AGAP3
Band7q36.1Start151,085,831 bp[1]
End151,144,436 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for AGAP3
Genomic location for AGAP3
Band5|5 A3Start24,657,175 bp[2]
End24,707,045 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • Brodmann area 9

  • cingulate gyrus

  • anterior cingulate cortex

  • prefrontal cortex

  • amygdala

  • hypothalamus

  • nucleus accumbens

  • anterior pituitary
Top expressed in
  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • neural layer of retina

  • ventricular zone

  • lip

  • muscle of thigh

  • cerebellar cortex

  • otic vesicle

  • saccule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • metal ion binding
  • GTPase activator activity
  • GTPase activity
  • polyubiquitin modification-dependent protein binding
Cellular component
  • membrane
  • nucleus
  • cytoplasm
  • cell periphery
Biological process
  • positive regulation of GTPase activity
  • signal transduction
  • cellular response to reactive oxygen species
  • proteasome-mediated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116988

213990

Ensembl

ENSG00000133612

ENSMUSG00000023353

UniProt

Q96P47
Q86ST5

Q8VHH5

RefSeq (mRNA)
NM_001042535
NM_001281300
NM_001308304
NM_001308305
NM_031946

NM_001350102
NM_001350103
NM_001350104

NM_001256431
NM_139153
NM_001359881

RefSeq (protein)
NP_001036000
NP_001268229
NP_001295233
NP_001295234
NP_114152

NP_001337031
NP_001337032
NP_001337033
NP_001036000.1
NP_001295233.1
NP_001295234.1

n/a

Location (UCSC)Chr 7: 151.09 – 151.14 MbChr 5: 24.66 – 24.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133612 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023353 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CENTG3 centaurin, gamma 3".

Further reading

  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Qin Q, Inatome R, Hotta A, et al. (2006). "A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein". J. Cell Biol. 172 (4): 497–504. doi:10.1083/jcb.200505079. PMC 2063670. PMID 16461359.
  • Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–49354. doi:10.1074/jbc.M410565200. PMID 15381706.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484–51493. doi:10.1074/jbc.M305622200. PMID 14506264.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Xia C, Ma W, Stafford LJ, et al. (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–2488. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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