CEP72

Protein-coding gene in the species Homo sapiens
CEP72
Identifiers
AliasesCEP72, centrosomal protein 72
External IDsOMIM: 616475; MGI: 1921720; HomoloGene: 10027; GeneCards: CEP72; OMA:CEP72 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CEP72
Genomic location for CEP72
Band5p15.33Start612,340 bp[1]
End667,168 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for CEP72
Genomic location for CEP72
Band13|13 C1Start74,184,619 bp[2]
End74,210,418 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • testicle

  • ventricular zone

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • left testis

  • right testis

  • ganglionic eminence

  • sural nerve

  • right frontal lobe
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • genital tubercle

  • otic vesicle

  • tail of embryo

  • ventricular zone

  • epiblast

  • morula

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
Cellular component
  • cytoplasm
  • microtubule organizing center
  • cytosol
  • centrosome
  • centriolar satellite
  • cytoskeleton
Biological process
  • gamma-tubulin complex localization
  • centriole replication
  • spindle organization
  • G2/M transition of mitotic cell cycle
  • regulation of protein localization to centrosome
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55722

74470

Ensembl

ENSG00000280688
ENSG00000112877

ENSMUSG00000021572

UniProt

Q9P209

Q9D3R3

RefSeq (mRNA)

NM_018140

NM_028959

RefSeq (protein)

NP_060610

NP_083235

Location (UCSC)Chr 5: 0.61 – 0.67 MbChr 13: 74.18 – 74.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 72 kDa is a protein that in humans is encoded by the CEP72 gene.[5][6]

The product of this gene is a member of the Leucine-rich repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.[6]

References

  1. ^ a b c ENSG00000112877 GRCh38: Ensembl release 89: ENSG00000280688, ENSG00000112877 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021572 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  6. ^ a b "Entrez Gene: CEP72 centrosomal protein 72kDa".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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