CHD5

Protein-coding gene in the species Homo sapiens

CHD5
Identifiers
AliasesCHD5, CHD-5, chromodomain helicase DNA binding protein 5, PMNDS
External IDsOMIM: 610771; MGI: 3036258; HomoloGene: 56712; GeneCards: CHD5; OMA:CHD5 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CHD5
Genomic location for CHD5
Band1p36.31Start6,101,787 bp[1]
End6,180,321 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for CHD5
Genomic location for CHD5
Band4|4 E2Start152,423,108 bp[2]
End152,474,651 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • right frontal lobe

  • cingulate gyrus

  • anterior cingulate cortex

  • Brodmann area 10

  • Brodmann area 9

  • pituitary gland

  • left testis

  • right testis

  • primary visual cortex
Top expressed in
  • subiculum

  • central gray substance of midbrain

  • dorsal tegmental nucleus

  • cingulate gyrus

  • visual cortex

  • habenula

  • lateral hypothalamus

  • primary visual cortex

  • medial vestibular nucleus

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • nucleotide binding
  • helicase activity
  • metal ion binding
  • H3K27me3 modified histone binding
  • hydrolase activity
  • ATP binding
Cellular component
  • NuRD complex
  • membrane
  • heterochromatin
  • nucleus
  • nucleoplasm
  • cytosol
  • nuclear speck
Biological process
  • cell differentiation
  • regulation of transcription, DNA-templated
  • histone H3-K27 trimethylation
  • positive regulation of signal transduction by p53 class mediator
  • transcription, DNA-templated
  • nervous system development
  • spermatogenesis
  • histone H4 acetylation
  • cerebral cortex neuron differentiation
  • negative regulation of cell population proliferation
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26038

269610

Ensembl

ENSG00000116254

ENSMUSG00000005045

UniProt

Q8TDI0

A2A8L1

RefSeq (mRNA)

NM_015557

NM_001081376
NM_029216
NM_001369243

RefSeq (protein)

NP_056372

NP_001074845
NP_083492
NP_001356172

Location (UCSC)Chr 1: 6.1 – 6.18 MbChr 4: 152.42 – 152.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene.[5][6][7] It is a part of the CHD subfamily of ATP-dependent chromatin remodeling complexes.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116254 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005045 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561. S2CID 1694959.
  6. ^ Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.
  7. ^ "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
  • Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Bagchi A, Papazoglu C, Wu Y, et al. (2007). "CHD5 is a tumor suppressor at human 1p36". Cell. 128 (3): 459–75. doi:10.1016/j.cell.2006.11.052. PMID 17289567. S2CID 13437928.
  • v
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  • 1mm2: Solution structure of the 2nd PHD domain from Mi2b
    1mm2: Solution structure of the 2nd PHD domain from Mi2b


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