CHMP4C

Protein-coding gene in the species Homo sapiens
CHMP4C
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3C3R

Identifiers
AliasesCHMP4C, SNF7-3, Shax3, VPS32C, charged multivesicular body protein 4C
External IDsOMIM: 610899; MGI: 1913621; HomoloGene: 23544; GeneCards: CHMP4C; OMA:CHMP4C - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for CHMP4C
Genomic location for CHMP4C
Band8q21.13Start81,732,448 bp[1]
End81,759,515 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CHMP4C
Genomic location for CHMP4C
Band3|3 A1Start10,431,967 bp[2]
End10,493,916 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amniotic fluid

  • jejunal mucosa

  • mucosa of ileum

  • skin of arm

  • palpebral conjunctiva

  • parotid gland

  • duodenum

  • pancreatic epithelial cell

  • gingival epithelium

  • mucosa of colon
Top expressed in
  • interventricular septum

  • ileum

  • duodenum

  • jejunum

  • epithelium of stomach

  • Paneth cell

  • left colon

  • ascending aorta

  • parotid gland

  • epithelium of small intestine
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein homodimerization activity
  • protein binding
Cellular component
  • cytoplasm
  • ESCRT III complex
  • cytosol
  • endosome
  • membrane
  • late endosome membrane
  • midbody
  • Flemming body
Biological process
  • regulation of centrosome duplication
  • abscission
  • viral budding via host ESCRT complex
  • viral life cycle
  • nucleus organization
  • multivesicular body assembly
  • regulation of mitotic spindle assembly
  • endosomal transport
  • ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
  • protein transport
  • negative regulation of cytokinesis
  • septum digestion after cytokinesis
  • mitotic metaphase plate congression
  • vacuolar transport
  • macroautophagy
  • mitotic cytokinesis checkpoint signaling
  • midbody abscission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

92421

66371

Ensembl

ENSG00000164695

ENSMUSG00000027536

UniProt

Q96CF2

Q9D7F7

RefSeq (mRNA)

NM_152284

NM_025519

RefSeq (protein)

NP_689497

NP_079795

Location (UCSC)Chr 8: 81.73 – 81.76 MbChr 3: 10.43 – 10.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Charged multivesicular body protein 4c is a protein that in humans is encoded by the CHMP4C gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164695 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027536 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M (Sep 2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J Biol Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
  6. ^ Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
  7. ^ "Entrez Gene: CHMP4C chromatin modifying protein 4C".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
  • von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
  • Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
  • Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.


  • v
  • t
  • e