CKS2

Protein-coding gene in the species Homo sapiens

CKS2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1CKS, 4Y72, 5HQ0, 4YC3

Identifiers

Aliases

CKS2, CKSHS2, CDC28 protein kinase regulatory subunit 2

External IDs

OMIM: 116901; MGI: 1913447; HomoloGene: 86883; GeneCards: CKS2; OMA:CKS2 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q22.2	Start	89,311,195 bp^[1]
Band	9q22.2	End	89,316,703 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 A5	Start	51,799,268 bp^[2]
Band	13\|13 A5	End	51,804,696 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

right testis

left testis

testicle

ganglionic eminence

sperm

oocyte

trabecular bone

gonad

mucosa of transverse colon

Top expressed in

morula

zygote

secondary oocyte

primary oocyte

embryo

epiblast

ventricular zone

embryo

yolk sac

blastocyst

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cyclin-dependent protein serine/threonine kinase regulator activity chromatin binding histone binding protein kinase binding cyclin-dependent protein serine/threonine kinase activator activity ubiquitin binding protein binding
Cellular component	SCF ubiquitin ligase complex cyclin-dependent protein kinase holoenzyme complex
Biological process	cell cycle meiosis I cell division regulation of mitotic cell cycle positive regulation of cyclin-dependent protein serine/threonine kinase activity cell population proliferation positive regulation of transcription, DNA-templated mitotic cell cycle phase transition regulation of transcription by RNA polymerase II regulation of cyclin-dependent protein serine/threonine kinase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1164


66197

Ensembl


ENSG00000123975


ENSMUSG00000062248

UniProt


P33552


P56390

RefSeq (mRNA)


NM_001827


NM_025415

RefSeq (protein)


NP_001818


NP_079691

Location (UCSC)

Chr 9: 89.31 – 89.32 Mb

Chr 13: 51.8 – 51.8 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene.^[5]^[6]^[7]

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123975 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062248 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Richardson HE, Stueland CS, Thomas J, Russell P, Reed SI (Dec 1990). "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe". Genes Dev. 4 (8): 1332–44. doi:10.1101/gad.4.8.1332. PMID 2227411.
^ Demetrick DJ, Zhang H, Beach DH (Sep 1996). "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22". Cytogenet Cell Genet. 73 (3): 250–4. doi:10.1159/000134349. PMID 8697818.
^ ^a ^b "Entrez Gene: CKS2 CDC28 protein kinase regulatory subunit 2".

External links

Human CKS2 genome location and CKS2 gene details page in the UCSC Genome Browser.

Parge HE, Arvai AS, Murtari DJ, et al. (1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control". Science. 262 (5132): 387–95. Bibcode:1993Sci...262..387P. doi:10.1126/science.8211159. PMID 8211159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
Gorr IH, Boos D, Stemmann O (2005). "Mutual inhibition of separase and Cdk1 by two-step complex formation". Mol. Cell. 19 (1): 135–41. doi:10.1016/j.molcel.2005.05.022. PMID 15989971.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rother K, Dengl M, Lorenz J, et al. (2007). "Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73". FEBS Lett. 581 (6): 1166–72. doi:10.1016/j.febslet.2007.02.028. PMID 17336302. S2CID 6953397.
Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen". PLOS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC 1831731. PMID 17388661.