CLDN18

Protein-coding gene in the species Homo sapiens
CLDN18
Identifiers
AliasesCLDN18, SFTA5, SFTPJ, claudin 18
External IDsOMIM: 609210; MGI: 1929209; HomoloGene: 9489; GeneCards: CLDN18; OMA:CLDN18 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CLDN18
Genomic location for CLDN18
Band3q22.3Start137,998,735 bp[1]
End138,033,655 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CLDN18
Genomic location for CLDN18
Band9|9 E3.3Start99,571,514 bp[2]
End99,599,320 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pylorus

  • lower lobe of lung

  • cardia

  • right lung

  • upper lobe of lung

  • upper lobe of left lung

  • body of stomach

  • gastric mucosa

  • visceral pleura

  • fundus
Top expressed in
  • mucous cell of stomach

  • right lung lobe

  • epithelium of stomach

  • pyloric antrum

  • left lung

  • left lung lobe

  • blastocyst

  • duodenum

  • embryo

  • right kidney
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • structural molecule activity
  • identical protein binding
Cellular component
  • integral component of membrane
  • cell junction
  • plasma membrane
  • membrane
  • bicellular tight junction
Biological process
  • negative regulation of protein localization to nucleus
  • TNFSF11-mediated signaling pathway
  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
  • digestive tract development
  • negative regulation of osteoclast development
  • negative regulation of bone resorption
  • response to ethanol
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51208

56492

Ensembl

ENSG00000066405

ENSMUSG00000032473

UniProt

P56856

P56857

RefSeq (mRNA)

NM_016369
NM_001002026

NM_001194921
NM_001194922
NM_001194923
NM_019815

RefSeq (protein)

NP_001002026
NP_057453

NP_001181850
NP_001181851
NP_001181852
NP_062789

Location (UCSC)Chr 3: 138 – 138.03 MbChr 9: 99.57 – 99.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[5] It belongs to the group of claudins.

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[6] [supplied by OMIM][5]

Clinical significance

Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[7]

Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000066405 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032473 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CLDN18 claudin 18".
  6. ^ Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911. PMID 11585919.
  7. ^ a b Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016

Further reading

  • Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
  • Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
  • Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
  • Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
  • González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Matsuda Y, Semba S, Ueda J, et al. (2007). "Gastric and intestinal claudin expression at the invasive front of gastric carcinoma". Cancer Sci. 98 (7): 1014–9. doi:10.1111/j.1349-7006.2007.00490.x. PMC 11159341. PMID 17459057. S2CID 28029778.
  • Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.


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