CNOT6

Protein-coding gene in the species Homo sapiens
CNOT6
Identifiers
AliasesCNOT6, CCR4, Ccr4a, CCR4-NOT transcription complex subunit 6
External IDsOMIM: 608951; MGI: 2144529; HomoloGene: 69187; GeneCards: CNOT6; OMA:CNOT6 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CNOT6
Genomic location for CNOT6
Band5q35.3Start180,494,379 bp[1]
End180,578,358 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CNOT6
Genomic location for CNOT6
Band11|11 B1.2Start49,562,330 bp[2]
End49,603,550 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • buccal mucosa cell

  • cerebellar vermis

  • ganglionic eminence

  • ventricular zone

  • retinal pigment epithelium

  • epithelium of nasopharynx

  • trabecular bone

  • amniotic fluid

  • bronchial epithelial cell
Top expressed in
  • retinal pigment epithelium

  • saccule

  • otic vesicle

  • ciliary body

  • ureter

  • medial ganglionic eminence

  • cumulus cell

  • superior cervical ganglion

  • trigeminal ganglion

  • otic placode
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • poly(A)-specific ribonuclease activity
  • exoribonuclease activity
  • metal ion binding
  • protein binding
  • RNA binding
  • nuclease activity
  • exonuclease activity
  • hydrolase activity
  • 3'-5'-exoribonuclease activity
Cellular component
  • cytoplasm
  • cytosol
  • membrane
  • CCR4-NOT complex
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • nucleic acid phosphodiester bond hydrolysis
  • transcription, DNA-templated
  • positive regulation of cytoplasmic mRNA processing body assembly
  • gene silencing by miRNA
  • positive regulation of cell population proliferation
  • exonucleolytic catabolism of deadenylated mRNA
  • gene silencing
  • nuclear-transcribed mRNA catabolic process, no-go decay
  • regulation of translation
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • RNA phosphodiester bond hydrolysis, exonucleolytic
  • nuclear-transcribed mRNA poly(A) tail shortening
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57472

104625

Ensembl

ENSG00000113300

ENSMUSG00000020362

UniProt

Q9ULM6

Q8K3P5

RefSeq (mRNA)

NM_001303241
NM_015455
NM_001370472
NM_001370473
NM_001370474

NM_001290741
NM_212484
NM_001363356
NM_001363357

RefSeq (protein)

NP_001290170
NP_001357401
NP_001357402
NP_001357403

NP_001277670
NP_997649
NP_001350285
NP_001350286

Location (UCSC)Chr 5: 180.49 – 180.58 MbChr 11: 49.56 – 49.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.[5][6]

The protein encoded by this gene is a subunit of the CCR4-Not transcriptional regulation and deadenylase complex. The encoded protein has a 3'-5' exonuclease activity and prefers polyadenylated substates.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113300 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020362 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen J, Chiang YC, Denis CL (Mar 2002). "CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase". EMBO J. 21 (6): 1414–26. doi:10.1093/emboj/21.6.1414. PMC 125924. PMID 11889047.
  6. ^ a b "Entrez Gene: CNOT6 CCR4-NOT transcription complex, subunit 6".

Further reading

  • Okubo K, Itoh K, Fukushima A, et al. (1996). "Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles". Genomics. 30 (2): 178–86. doi:10.1006/geno.1995.9887. PMID 8586417.
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Albert TK, Lemaire M, van Berkum NL, et al. (2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  • Dupressoir A, Morel AP, Barbot W, et al. (2003). "Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding". BMC Genomics. 2: 9. doi:10.1186/1471-2164-2-9. PMC 61044. PMID 11747467.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Chang TC, Yamashita A, Chen CY, et al. (2004). "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant". Genes Dev. 18 (16): 2010–23. doi:10.1101/gad.1219104. PMC 514181. PMID 15314026.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.


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