CNOT6 |
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Identifiers |
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Aliases | CNOT6, CCR4, Ccr4a, CCR4-NOT transcription complex subunit 6 |
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External IDs | OMIM: 608951; MGI: 2144529; HomoloGene: 69187; GeneCards: CNOT6; OMA:CNOT6 - orthologs |
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Gene location (Human) |
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![Chromosome 5 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png) | Chr. | Chromosome 5 (human)[1] |
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| Band | 5q35.3 | Start | 180,494,379 bp[1] |
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End | 180,578,358 bp[1] |
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Gene location (Mouse) |
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![Chromosome 11 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 B1.2 | Start | 49,562,330 bp[2] |
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End | 49,603,550 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - secondary oocyte
- buccal mucosa cell
- cerebellar vermis
- ganglionic eminence
- ventricular zone
- retinal pigment epithelium
- epithelium of nasopharynx
- trabecular bone
- amniotic fluid
- bronchial epithelial cell
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| Top expressed in | - retinal pigment epithelium
- saccule
- otic vesicle
- ciliary body
- ureter
- medial ganglionic eminence
- cumulus cell
- superior cervical ganglion
- trigeminal ganglion
- otic placode
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a6/PBB_GE_CNOT6_gnf1h02366_at_fs.png/250px-PBB_GE_CNOT6_gnf1h02366_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/3/36/PBB_GE_CNOT6_217970_s_at_fs.png/250px-PBB_GE_CNOT6_217970_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - poly(A)-specific ribonuclease activity
- exoribonuclease activity
- metal ion binding
- protein binding
- RNA binding
- nuclease activity
- exonuclease activity
- hydrolase activity
- 3'-5'-exoribonuclease activity
| Cellular component | - cytoplasm
- cytosol
- membrane
- CCR4-NOT complex
- nucleus
| Biological process | - regulation of transcription, DNA-templated
- nucleic acid phosphodiester bond hydrolysis
- transcription, DNA-templated
- positive regulation of cytoplasmic mRNA processing body assembly
- gene silencing by miRNA
- positive regulation of cell population proliferation
- exonucleolytic catabolism of deadenylated mRNA
- gene silencing
- nuclear-transcribed mRNA catabolic process, no-go decay
- regulation of translation
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- RNA phosphodiester bond hydrolysis, exonucleolytic
- nuclear-transcribed mRNA poly(A) tail shortening
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001303241 NM_015455 NM_001370472 NM_001370473 NM_001370474 |
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NM_001290741 NM_212484 NM_001363356 NM_001363357 |
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RefSeq (protein) | |
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NP_001290170 NP_001357401 NP_001357402 NP_001357403 |
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NP_001277670 NP_997649 NP_001350285 NP_001350286 |
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Location (UCSC) | Chr 5: 180.49 – 180.58 Mb | Chr 11: 49.56 – 49.6 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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