CNOT7

Protein-coding gene in the species Homo sapiens

CNOT7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2D5R, 4GMJ

Identifiers
AliasesCNOT7, CAF1, Caf1a, hCAF-1, CAF-1, CCR4-NOT transcription complex subunit 7
External IDsOMIM: 604913; MGI: 1298230; HomoloGene: 49011; GeneCards: CNOT7; OMA:CNOT7 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for CNOT7
Genomic location for CNOT7
Band8p22Start17,224,966 bp[1]
End17,246,878 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CNOT7
Genomic location for CNOT7
Band8|8 A4Start40,945,581 bp[2]
End40,968,888 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • buccal mucosa cell

  • corpus epididymis

  • secondary oocyte

  • germinal epithelium

  • Skeletal muscle tissue of biceps brachii

  • caput epididymis

  • parotid gland

  • Skeletal muscle tissue of rectus abdominis

  • tail of epididymis
Top expressed in
  • superior cervical ganglion

  • cumulus cell

  • medial ganglionic eminence

  • tail of embryo

  • secondary oocyte

  • genital tubercle

  • medullary collecting duct

  • dorsal striatum

  • ureter

  • abdominal wall
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nuclease activity
  • nucleic acid binding
  • exoribonuclease activity
  • protein binding
  • 3'-5'-exoribonuclease activity
  • signal transducer activity
  • poly(A)-specific ribonuclease activity
  • exonuclease activity
  • RNA binding
  • DNA-binding transcription factor activity
  • hydrolase activity
  • metal ion binding
  • transcription factor binding
  • transcription corepressor activity
Cellular component
  • nucleus
  • CCR4-NOT complex
  • cytosol
  • membrane
  • nuclear body
  • P-body
  • cytoplasm
  • nuclear speck
  • CCR4-NOT core complex
  • host cell PML body
Biological process
  • negative regulation of cell population proliferation
  • negative regulation of gene expression
  • exonucleolytic catabolism of deadenylated mRNA
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • nucleic acid phosphodiester bond hydrolysis
  • P-body assembly
  • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • regulation of transcription, DNA-templated
  • positive regulation of cell population proliferation
  • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  • positive regulation of transcription by RNA polymerase II
  • positive regulation of mRNA catabolic process
  • gene silencing by miRNA
  • regulation of translation
  • nuclear-transcribed mRNA poly(A) tail shortening
  • signal transduction
  • gene silencing
  • transcription, DNA-templated
  • RNA phosphodiester bond hydrolysis, exonucleolytic
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • negative regulation of transcription by RNA polymerase II
  • regulation of tyrosine phosphorylation of STAT protein
  • positive regulation of viral genome replication
  • negative regulation of transcription, DNA-templated
  • defense response to virus
  • negative regulation of type I interferon-mediated signaling pathway
  • carbohydrate metabolic process
  • negative regulation of translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29883

18983

Ensembl

ENSG00000198791

ENSMUSG00000031601

UniProt

Q9UIV1

Q60809

RefSeq (mRNA)
NM_013354
NM_054026
NM_001322087
NM_001322088
NM_001322089

NM_001322090
NM_001322091
NM_001322092
NM_001322093
NM_001322094
NM_001322095
NM_001322096
NM_001322097
NM_001322098
NM_001322099
NM_001322100

NM_001271542
NM_001271543
NM_011135
NM_001361938
NM_001361939

RefSeq (protein)
NP_001309016
NP_001309017
NP_001309018
NP_001309019
NP_001309020

NP_001309021
NP_001309022
NP_001309023
NP_001309024
NP_001309025
NP_001309026
NP_001309027
NP_001309028
NP_001309029
NP_037486
NP_473367

NP_001258471
NP_001258472
NP_035265
NP_001348867
NP_001348868

Location (UCSC)Chr 8: 17.22 – 17.25 MbChr 8: 40.95 – 40.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene.[5][6][7][8] It is a subunit of the CCR4-Not deadenylase complex.

Function

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[8]

Interactions

CNOT7 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198791 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031601 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  6. ^ Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (March 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.
  7. ^ Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J. Cell Sci. 120 (Pt 4): 638–47. doi:10.1242/jcs.03357. PMID 17264152. S2CID 6592326.
  8. ^ a b "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7".
  9. ^ Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (2): 471–81. doi:10.1042/bj3360471. PMC 1219893. PMID 9820826.
  10. ^ Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  11. ^ a b Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC 2081979. PMID 18056425.
  12. ^ a b Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (December 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.

Further reading

  • Draper MP, Salvadore C, Denis CL (1995). "Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex". Mol. Cell. Biol. 15 (7): 3487–95. doi:10.1128/MCB.15.7.3487. PMC 230585. PMID 7791755.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Rouault JP, Prévôt D, Berthet C, Birot AM, Billaud M, Magaud JP, Corbo L (1998). "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex". J. Biol. Chem. 273 (35): 22563–9. doi:10.1074/jbc.273.35.22563. PMID 9712883.
  • Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (2): 471–81. doi:10.1042/bj3360471. PMC 1219893. PMID 9820826.
  • Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
  • Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  • Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753. PMID 11429045.
  • Flanagan J, Healey S, Young J, Whitehall V, Chenevix-Trench G (2003). "Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer". Int. J. Cancer. 106 (4): 505–9. doi:10.1002/ijc.11264. PMID 12845644. S2CID 25191544.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Human CNOT7 genome location and CNOT7 gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: Q9UIV1 (CCR4-NOT transcription complex subunit 7) at the PDBe-KB.
  • v
  • t
  • e
  • 2d5r: Crystal Structure of a Tob-hCaf1 Complex
    2d5r: Crystal Structure of a Tob-hCaf1 Complex


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