CNPY2

Identifiers

Aliases

CNPY2, HP10390, MSAP, TMEM4, ZSIG9, canopy FGF signaling regulator 2

External IDs

OMIM: 605861; MGI: 1928477; HomoloGene: 40934; GeneCards: CNPY2; OMA:CNPY2 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.3	Start	56,309,842 bp^[1]
Band	12q13.3	End	56,316,119 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 D3\|10 76.52 cM	Start	128,158,328 bp^[2]
Band	10 D3\|10 76.52 cM	End	128,163,422 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

anterior pituitary

stromal cell of endometrium

body of pancreas

right lobe of thyroid gland

right adrenal cortex

left adrenal cortex

left lobe of thyroid gland

right lobe of liver

right ovary

mucosa of transverse colon

Top expressed in

medullary collecting duct

fossa

vas deferens

seminal vesicula

condyle

lacrimal gland

efferent ductule

primitive streak

Epithelium of choroid plexus

molar

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding
Cellular component	integral component of plasma membrane endoplasmic reticulum
Biological process	negative regulation of gene expression regulation of low-density lipoprotein particle clearance tissue development enzyme linked receptor protein signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10330


56530

Ensembl


ENSG00000257727


ENSMUSG00000025381

UniProt


Q9Y2B0


Q9QXT0

RefSeq (mRNA)


NM_014255 NM_001190991


NM_019953

RefSeq (protein)


NP_001177920 NP_055070


NP_064337

Location (UCSC)

Chr 12: 56.31 – 56.32 Mb

Chr 10: 128.16 – 128.16 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Canopy FGF signaling regulator 2 is a protein that in humans is encoded by the CNPY2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000257727 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025381 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Canopy FGF signaling regulator 2".

Bornhauser BC, Lindholm D (June 2005). "MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain". Cellular and Molecular Life Sciences. 62 (11): 1260–6. doi:10.1007/s00018-005-5055-x. PMC 11139096. PMID 15905959. S2CID 10306386.
Bornhauser BC, Olsson PA, Lindholm D (September 2003). "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain". The Journal of Biological Chemistry. 278 (37): 35412–20. doi:10.1074/jbc.M306271200. PMID 12826659.
Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (March 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
Do HT, Tselykh TV, Mäkelä J, Ho TH, Olkkonen VM, Bornhauser BC, Korhonen L, Zelcer N, Lindholm D (April 2012). "Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)". The Journal of Biological Chemistry. 287 (16): 12602–11. doi:10.1074/jbc.M112.341248. PMC 3339997. PMID 22378787.