CORO2A

Protein-coding gene in the species Homo sapiens
CORO2A
Identifiers
AliasesCORO2A, CLIPINB, IR10, WDR2, coronin 2A
External IDsOMIM: 602159; MGI: 1345966; HomoloGene: 2546; GeneCards: CORO2A; OMA:CORO2A - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for CORO2A
Genomic location for CORO2A
Band9q22.33Start98,120,975 bp[1]
End98,192,637 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for CORO2A
Genomic location for CORO2A
Band4|4 B1Start46,536,937 bp[2]
End46,602,202 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • duodenum

  • mucosa of transverse colon

  • gallbladder

  • human penis

  • bronchial epithelial cell

  • rectum

  • spinal ganglia

  • mucosa of pharynx

  • mucosa of sigmoid colon
Top expressed in
  • seminal vesicula

  • epithelium of small intestine

  • intestinal villus

  • ileum

  • colon

  • lumbar spinal ganglion

  • mucous cell of stomach

  • left colon

  • jejunum

  • spermatid
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • actin binding
  • actin filament binding
  • protein binding
Cellular component
  • actin cytoskeleton
  • transcription repressor complex
  • intracellular anatomical structure
Biological process
  • actin cytoskeleton organization
  • intracellular signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7464

107684

Ensembl

ENSG00000106789

ENSMUSG00000028337

UniProt

Q92828

Q8C0P5

RefSeq (mRNA)

NM_003389
NM_052820

NM_001164804
NM_178893

RefSeq (protein)

NP_003380
NP_438171

NP_001158276
NP_849224

Location (UCSC)Chr 9: 98.12 – 98.19 MbChr 4: 46.54 – 46.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.[5]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106789 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028337 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Coronin, actin binding protein, 2A". Retrieved 2012-01-03.

Further reading

  • Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
  • Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (September 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
  • Marshall TW, Aloor HL, Bear JE (September 2009). "Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway". Journal of Cell Science. 122 (Pt 17): 3061–9. doi:10.1242/jcs.051482. PMC 2729258. PMID 19654210.
  • Jin Y, Birlea SA, Fain PR, Mailloux CM, Riccardi SL, Gowan K, Holland PJ, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA (July 2010). "Common variants in FOXP1 are associated with generalized vitiligo". Nature Genetics. 42 (7): 576–8. doi:10.1038/ng.602. PMC 2893242. PMID 20526340.
  • Zaphiropoulos PG, Toftgård R (December 1996). "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region". DNA and Cell Biology. 15 (12): 1049–56. doi:10.1089/dna.1996.15.1049. PMID 8985118.
  • v
  • t
  • e