CREG1

Protein-coding gene in the species Homo sapiens
CREG1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1XHN

Identifiers
AliasesCREG1, CREG, cellular repressor of E1A stimulated genes 1
External IDsOMIM: 618055; MGI: 1344382; HomoloGene: 31199; GeneCards: CREG1; OMA:CREG1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CREG1
Genomic location for CREG1
Band1q24.2Start167,529,117 bp[1]
End167,553,805 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CREG1
Genomic location for CREG1
Band1|1 H2.3Start165,591,315 bp[2]
End165,602,877 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of thigh

  • hair follicle

  • vulva

  • skin of arm

  • gallbladder

  • parotid gland

  • lower lobe of lung

  • skin of hip

  • gingival epithelium

  • trabecular bone
Top expressed in
  • blood

  • stroma of bone marrow

  • left lobe of liver

  • epithelium of stomach

  • fetal liver hematopoietic progenitor cell

  • transitional epithelium of urinary bladder

  • saccule

  • otic placode

  • lacrimal gland

  • tibiofemoral joint
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transcription factor binding
  • transcription corepressor activity
Cellular component
  • extracellular exosome
  • transcription regulator complex
  • extracellular region
  • extracellular space
  • azurophil granule lumen
Biological process
  • regulation of transcription by RNA polymerase II
  • multicellular organism development
  • regulation of growth
  • cell population proliferation
  • regulation of transcription, DNA-templated
  • negative regulation of nucleic acid-templated transcription
  • neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8804

433375

Ensembl

ENSG00000143162

ENSMUSG00000040713

UniProt

O75629

O88668

RefSeq (mRNA)

NM_003851

NM_011804

RefSeq (protein)

NP_003842

NP_035934

Location (UCSC)Chr 1: 167.53 – 167.55 MbChr 1: 165.59 – 165.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a protein that in humans is encoded by the CREG1 gene.[5][6]

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143162 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040713 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Veal E, Eisenstein M, Tseng ZH, Gill G (Sep 1998). "A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F". Mol Cell Biol. 18 (9): 5032–41. doi:10.1128/mcb.18.9.5032. PMC 109088. PMID 9710587.
  6. ^ a b "Entrez Gene: CREG1 cellular repressor of E1A-stimulated genes 1".

Further reading

  • Veal E, Groisman R, Eisenstein M, Gill G (2000). "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells". Oncogene. 19 (17): 2120–8. doi:10.1038/sj.onc.1203529. PMID 10815803.
  • Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Di Bacco A, Gill G (2003). "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor". Oncogene. 22 (35): 5436–45. doi:10.1038/sj.onc.1206670. PMID 12934103.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Sacher M, Di Bacco A, Lunin VV, et al. (2006). "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18326–31. doi:10.1073/pnas.0505071102. PMC 1317909. PMID 16344469.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • v
  • t
  • e
  • 1xhn: The crystal structure of Cellular Repressor of E1A-stimulated Genes (CREG)
    1xhn: The crystal structure of Cellular Repressor of E1A-stimulated Genes (CREG)


Stub icon

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e