CRISP2

Protein-coding gene in the species Homo sapiens
CRISP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CQ7

Identifiers
AliasesCRISP2, CRISP-2, CT36, GAPDL5, TPX1, TSP1, cysteine rich secretory protein 2
External IDsOMIM: 187430; MGI: 98815; HomoloGene: 37756; GeneCards: CRISP2; OMA:CRISP2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CRISP2
Genomic location for CRISP2
Band6p12.3Start49,692,358 bp[1]
End49,713,590 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for CRISP2
Genomic location for CRISP2
Band17 B2|17 19.54 cMStart41,074,911 bp[2]
End41,117,894 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • left testis

  • right testis

  • right uterine tube

  • pancreatic ductal cell

  • testicle

  • bronchial epithelial cell

  • minor salivary glands

  • caput epididymis

  • gallbladder
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • embryo

  • epithelium of lens

  • muscle tissue

  • white adipose tissue

  • islet of Langerhans

  • striated muscle tissue

  • skeletal muscle tissue
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7180

22024

Ensembl

ENSG00000124490

ENSMUSG00000023930

UniProt

P16562

P16563

RefSeq (mRNA)
NM_001142407
NM_001142408
NM_001142417
NM_001142435
NM_001261822

NM_003296

NM_001204071
NM_009420

RefSeq (protein)
NP_001135879
NP_001135880
NP_001135889
NP_001135907
NP_001248751

NP_003287

NP_001191000
NP_033446

Location (UCSC)Chr 6: 49.69 – 49.71 MbChr 17: 41.07 – 41.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine-rich secretory protein 2 is a cysteine-rich secretory protein that in humans is encoded by the CRISP2 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124490 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023930 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kasahara M, Gutknecht J, Brew K, Spurr N, Goodfellow PN (Mar 1990). "Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene". Genomics. 5 (3): 527–34. doi:10.1016/0888-7543(89)90019-0. PMID 2613236.
  6. ^ Kratzschmar J, Haendler B, Eberspaecher U, Roosterman D, Donner P, Schleuning WD (Aug 1996). "The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3". Eur J Biochem. 236 (3): 827–36. doi:10.1111/j.1432-1033.1996.t01-1-00827.x. PMID 8665901.
  7. ^ "Entrez Gene: CRISP2 cysteine-rich secretory protein 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Busso D, Cohen DJ, Hayashi M, et al. (2005). "Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction". Mol. Hum. Reprod. 11 (4): 299–305. doi:10.1093/molehr/gah156. hdl:11336/31466. PMID 15734896.
  • Du Y, Huang X, Li J, et al. (2006). "Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility". Fertil. Steril. 85 (6): 1852–4. doi:10.1016/j.fertnstert.2005.11.064. PMID 16759931.


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