CSRP1

Protein-coding gene in the species Homo sapiens

CSRP1
Identifiers
AliasesCSRP1, CRP, CRP1, CSRP, CYRP, D1S181E, HEL-141, HEL-S-286, cysteine and glycine rich protein 1
External IDsOMIM: 123876; MGI: 88549; HomoloGene: 37874; GeneCards: CSRP1; OMA:CSRP1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CSRP1
Genomic location for CSRP1
Band1q32.1Start201,483,530 bp[1]
End201,509,456 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CSRP1
Genomic location for CSRP1
Band1|1 E4Start135,647,799 bp[2]
End135,679,970 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • popliteal artery

  • tibial arteries

  • right coronary artery

  • muscle layer of sigmoid colon

  • saphenous vein

  • body of uterus

  • left uterine tube

  • gastric mucosa

  • tail of epididymis

  • smooth muscle tissue
Top expressed in
  • ascending aorta

  • aortic valve

  • tunica media of zone of aorta

  • seminal vesicula

  • uterus

  • deep cerebellar nuclei

  • globus pallidus

  • belly cord

  • pyloric antrum

  • lateral geniculate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • RNA binding
  • zinc ion binding
Cellular component
  • extracellular exosome
  • focal adhesion
  • nucleus
Biological process
  • platelet aggregation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1465

13007

Ensembl

ENSG00000159176

ENSMUSG00000026421

UniProt

P21291

P97315

RefSeq (mRNA)

NM_004078
NM_001144773
NM_001193570
NM_001193571
NM_001193572

NM_007791
NM_001360782

RefSeq (protein)

NP_001180499
NP_001180500
NP_001180501
NP_004069

NP_031817
NP_001347711

Location (UCSC)Chr 1: 201.48 – 201.51 MbChr 1: 135.65 – 135.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine and glycine-rich protein 1 is a protein that in humans is encoded by the CSRP1 gene.[5][6][7]

CSRP1 is a member of the CSRP family of genes encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in CRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation Other genes in the family include CSRP2 and CSRP3.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159176 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026421 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (Aug 1990). "Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif". Nucleic Acids Res. 18 (13): 3871–9. doi:10.1093/nar/18.13.3871. PMC 331088. PMID 2115670.
  6. ^ Erdel M, Weiskirchen R (Mar 1999). "Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 10–1. doi:10.1159/000015152. PMID 9925910. S2CID 28018584.
  7. ^ a b "Entrez Gene: CSRP1 cysteine and glycine-rich protein 1".

Further reading

  • Weiskirchen R, Günther K (2003). "The CRP/MLP/TLP family of LIM domain proteins: acting by connecting". BioEssays. 25 (2): 152–62. doi:10.1002/bies.10226. PMID 12539241. S2CID 21364125.
  • Wang X, Lee G, Liebhaber SA, Cooke NE (1992). "Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc". J. Biol. Chem. 267 (13): 9176–84. doi:10.1016/S0021-9258(19)50405-7. PMID 1374386.
  • Wang X, Ray K, Szpirer J, et al. (1992). "Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism". Genomics. 14 (2): 391–7. doi:10.1016/S0888-7543(05)80231-9. PMID 1385304.
  • Feuerstein R, Wang X, Song D, et al. (1994). "The LIM/double zinc-finger motif functions as a protein dimerization domain". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10655–9. Bibcode:1994PNAS...9110655F. doi:10.1073/pnas.91.22.10655. PMC 45080. PMID 7938009.
  • Dubé JY, Chapdelaine P, Trahan PL, et al. (1998). "Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate". Arch. Androl. 40 (2): 109–15. doi:10.3109/01485019808987933. PMID 9507743.
  • Harper BD, Beckerle MC, Pomiès P (2001). "Fine mapping of the alpha-actinin binding site within cysteine-rich protein". Biochem. J. 350 Pt 1 (Pt 1): 269–74. doi:10.1042/0264-6021:3500269. PMC 1221251. PMID 10926853.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Hirasawa Y, Arai M, Imazeki F, et al. (2007). "Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma". Oncology. 71 (1–2): 77–85. doi:10.1159/000100475. PMID 17341888. S2CID 40174270.
  • Wang Q, Williamson M, Bott S, et al. (2007). "Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer". Oncogene. 26 (45): 6560–5. doi:10.1038/sj.onc.1210472. PMID 17486081. S2CID 19222997.
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  • 1ctl: STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP
    1ctl: STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP


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