CTDSP2

Protein-coding gene in humans
CTDSP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2Q5E

Identifiers
AliasesCTDSP2, OS4, PSR2, SCP2, CTD small phosphatase 2
External IDsOMIM: 608711; MGI: 1098748; HomoloGene: 128791; GeneCards: CTDSP2; OMA:CTDSP2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CTDSP2
Genomic location for CTDSP2
Band12q14.1Start57,819,927 bp[1]
End57,846,729 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for CTDSP2
Genomic location for CTDSP2
Band10 D3|10 74.35 cMStart126,814,586 bp[2]
End126,835,844 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastric mucosa

  • stromal cell of endometrium

  • Descending thoracic aorta

  • body of uterus

  • left ovary

  • right coronary artery

  • right lung

  • right ovary

  • left uterine tube

  • muscle layer of sigmoid colon
Top expressed in
  • ventricular zone

  • lip

  • genital tubercle

  • zone of skin

  • urinary bladder

  • skeletal muscle tissue

  • muscle of thigh

  • esophagus

  • uterus

  • lung
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II CTD heptapeptide repeat phosphatase activity
  • phosphatase activity
  • protein binding
  • phosphoprotein phosphatase activity
  • hydrolase activity
  • metal ion binding
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • negative regulation of G1/S transition of mitotic cell cycle
  • negative regulation of protein phosphorylation
  • protein dephosphorylation
  • IRE1-mediated unfolded protein response
  • regulation of transcription by RNA polymerase II
  • dephosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10106

52468

Ensembl

ENSG00000175215

ENSMUSG00000078429

UniProt

O14595

Q8BX07

RefSeq (mRNA)

NM_005730

NM_001113470
NM_146012

RefSeq (protein)

NP_005721
NP_005721.3

NP_001106941
NP_666124

Location (UCSC)Chr 12: 57.82 – 57.85 MbChr 10: 126.81 – 126.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 is an enzyme that in humans is encoded by the CTDSP2 gene.[5][6][7]

Interactions

CTDSP2 has been shown to interact with SNAI1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175215 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078429 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Su YA, Lee MM, Hutter CM, Meltzer PS (September 1997). "Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas". Oncogene. 15 (11): 1289–94. doi:10.1038/sj.onc.1201294. PMID 9315096.
  6. ^ Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
  7. ^ "Entrez Gene: CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2".
  8. ^ Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.

Further reading

  • Su YA, Trent JM, Guan XY, Meltzer PS (September 1994). "Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection". Proceedings of the National Academy of Sciences of the United States of America. 91 (19): 9121–5. Bibcode:1994PNAS...91.9121S. doi:10.1073/pnas.91.19.9121. PMC 44759. PMID 8090779.
  • Beutler E, Gelbart T, West C, Kuhl W, Lee P (1996). "A strategy for cloning the hereditary hemochromatosis gene". Blood Cells, Molecules & Diseases. 21 (3): 207–16. doi:10.1006/bcmd.1995.0024. PMID 8673473.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Thompson J, Lepikhova T, Teixido-Travesa N, Whitehead MA, Palvimo JJ, Jänne OA (June 2006). "Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription". The EMBO Journal. 25 (12): 2757–67. doi:10.1038/sj.emboj.7601161. PMC 1500849. PMID 16724108.

External links


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