CUGBP2

Protein-coding gene in the species Homo sapiens

CELF2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2MY7, 2MY8, 4LJM, 4LMZ, 4TLQ

Identifiers

Aliases

CELF2, BRUNOL3, CUGBP2, ETR-3, ETR3, NAPOR, CELF-2, CUG-BP2, CUGBP, Elav-like family member 2, CUGBP Elav-like family member 2, DEE97

External IDs

OMIM: 602538; MGI: 1338822; HomoloGene: 4783; GeneCards: CELF2; OMA:CELF2 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p14	Start	10,798,397 bp^[1]
Band	10p14	End	11,336,675 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A1	Start	6,539,694 bp^[2]
Band	2\|2 A1	End	7,509,563 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Region I of hippocampus proper

orbitofrontal cortex

entorhinal cortex

trabecular bone

middle temporal gyrus

postcentral gyrus

Brodmann area 46

lateral nuclear group of thalamus

Brodmann area 23

germinal epithelium

Top expressed in

Rostral migratory stream

lateral septal nucleus

olfactory tubercle

nucleus accumbens

anterior amygdaloid area

subiculum

barrel cortex

ganglionic eminence

olfactory bulb

medial dorsal nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleic acid binding RNA binding pre-mRNA binding mRNA binding
Cellular component	cytoplasm nucleus ribonucleoprotein complex
Biological process	mRNA processing RNA processing regulation of heart contraction mRNA splice site selection regulation of alternative mRNA splicing, via spliceosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10659


14007

Ensembl


ENSG00000048740


ENSMUSG00000002107

UniProt


O95319


Q9Z0H4

RefSeq (mRNA)

NM_001025076
NM_001025077
NM_001083591
NM_006561
NM_001326317

NM_001326318
NM_001326319
NM_001326320
NM_001326321
NM_001326323
NM_001326324
NM_001326325
NM_001326326
NM_001326327
NM_001326328
NM_001326329
NM_001326330
NM_001326331
NM_001326332
NM_001326333
NM_001326334
NM_001326335
NM_001326336
NM_001326337
NM_001326338
NM_001326339
NM_001326340
NM_001326341
NM_001326342
NM_001326343
NM_001326344
NM_001326345
NM_001326346
NM_001326347
NM_001326348
NM_001326349
NM_001394502
NM_001394513
NM_001394517
NM_001394518
NM_001394519

NM_001110228 NM_001110229 NM_001110230 NM_001110231 NM_001110232
NM_001160292 NM_001160293 NM_010160 NM_183219 NM_001310447 NM_001347094

RefSeq (protein)

NP_001020247 NP_001020248 NP_001077060 NP_001313246 NP_001313247
NP_001313248 NP_001313249 NP_001313250 NP_001313252 NP_001313253 NP_001313254 NP_001313255 NP_001313256 NP_001313257 NP_001313258 NP_001313259 NP_001313260 NP_001313261 NP_001313262 NP_001313263 NP_001313264 NP_001313265 NP_001313266 NP_001313267 NP_001313268 NP_001313269 NP_001313270 NP_001313271 NP_001313272 NP_001313273 NP_001313274 NP_001313275 NP_001313276 NP_001313277 NP_001313278 NP_006552

NP_001103698
NP_001103699
NP_001103700
NP_001103701
NP_001103702

NP_001153764
NP_001153765
NP_001297376
NP_001334023
NP_034290
NP_001393762
NP_001393763
NP_001393764
NP_001393770
NP_001393771
NP_001393772
NP_001393773
NP_001393774
NP_001393775
NP_001393776
NP_001393777
NP_001393778
NP_001393779
NP_001393780
NP_001393781
NP_001393783
NP_001393784
NP_001393787
NP_001393846
NP_001393847
NP_001393848
NP_001393849
NP_001393850
NP_001393851
NP_001393852
NP_001393853
NP_001393854
NP_001393855
NP_001393856
NP_001393857
NP_001393858
NP_001393859
NP_001393860
NP_001393861
NP_001393862
NP_001393863
NP_001393871
NP_001393872
NP_001393873
NP_001393874
NP_001393875
NP_001393876
NP_001393877
NP_001393878
NP_001393879
NP_001393880
NP_001393881
NP_001393882
NP_001393883
NP_001393884
NP_001393885
NP_001393886
NP_001393887
NP_001393888
NP_001393889
NP_001393890
NP_001393891
NP_001393892
NP_001393893
NP_001393894
NP_001393895
NP_001393896
NP_001393897
NP_001393898
NP_001393899
NP_001393900
NP_001393901
NP_001393902
NP_001393903
NP_001393904
NP_001393905
NP_001393906
NP_001393907
NP_001393908
NP_001393909
NP_001393910
NP_001393911

Location (UCSC)

Chr 10: 10.8 – 11.34 Mb

Chr 2: 6.54 – 7.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CUGBP, Elav-like family member 2, also known as Etr-3 is a protein that in humans is encoded by the CELF2 gene.^[5]^[6]^[7]

Members of the CELF/BRUNOL protein family are RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.^[7]

Interactions

CUGBP2 has been shown to interact with A1CF.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000048740 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002107 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hwang DM, Hwang WS, Liew CC (Mar 1995). "Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system". J Mol Cell Cardiol. 26 (10): 1329–33. doi:10.1006/jmcc.1994.1151. PMID 7869393.
^ Lu X, Timchenko NA, Timchenko LT (Mar 1999). "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy". Hum Mol Genet. 8 (1): 53–60. doi:10.1093/hmg/8.1.53. PMID 9887331.
^ ^a ^b "Entrez Gene: CELF2 CUGBP, Elav-like family member 2".
^ Anant, S; Henderson J O; Mukhopadhyay D; Navaratnam N; Kennedy S; Min J; Davidson N O (Dec 2001). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50). United States: 47338–51. doi:10.1074/jbc.M104911200. ISSN 0021-9258. PMID 11577082.

External links

Human CELF2 genome location and CELF2 gene details page in the UCSC Genome Browser.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Choi DK, Ito T, Tsukahara F, et al. (1999). "Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein". Gene. 237 (1): 135–42. doi:10.1016/S0378-1119(99)00312-1. PMID 10524244.
Good PJ, Chen Q, Warner SJ, Herring DC (2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J. Biol. Chem. 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
Ladd AN, Charlet N, Cooper TA (2001). "The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia". Genomics. 74 (3): 396–401. doi:10.1006/geno.2001.6558. PMID 11414768.
Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. PMID 11577082.
Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p". J. Mol. Med. 80 (7): 431–42. doi:10.1007/s00109-002-0331-9. PMID 12110949. S2CID 24098272.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mukhopadhyay D, Houchen CW, Kennedy S, et al. (2003). "Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2". Mol. Cell. 11 (1): 113–26. doi:10.1016/S1097-2765(03)00012-1. PMID 12535526.
Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
Mukhopadhyay D, Jung J, Murmu N, et al. (2004). "CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury". Ann. N. Y. Acad. Sci. 1010 (1): 504–9. Bibcode:2003NYASA1010..504M. doi:10.1196/annals.1299.093. PMID 15033780. S2CID 38581539.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Murmu N, Jung J, Mukhopadhyay D, et al. (2004). "Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13873–8. Bibcode:2004PNAS..10113873M. doi:10.1073/pnas.0406066101. PMC 518846. PMID 15358864.
Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Chen Z, Eggerman TL, Patterson AP (2007). "ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G53–65. doi:10.1152/ajpgi.00118.2006. PMID 16920700.