Protein found in humans
CALU |
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Identifiers |
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Aliases | CALU, calumenin |
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External IDs | OMIM: 603420; MGI: 1097158; HomoloGene: 936; GeneCards: CALU; OMA:CALU - orthologs |
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Gene location (Human) |
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![Chromosome 7 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/300px-Ideogram_human_chromosome_7.svg.png) | Chr. | Chromosome 7 (human)[1] |
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| Band | 7q32.1 | Start | 128,739,292 bp[1] |
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End | 128,773,400 bp[1] |
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Gene location (Mouse) |
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![Chromosome 6 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/260px-Ideogram_house_mouse_chromosome_6.svg.png) | Chr. | Chromosome 6 (mouse)[2] |
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| Band | 6|6 A3.3 | Start | 29,348,068 bp[2] |
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End | 29,377,109 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - stromal cell of endometrium
- smooth muscle tissue
- tendon of biceps brachii
- thoracic aorta
- ascending aorta
- right coronary artery
- Achilles tendon
- Descending thoracic aorta
- left coronary artery
- popliteal artery
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| Top expressed in | - gastrula
- calvaria
- dermis
- efferent ductule
- molar
- stroma of bone marrow
- belly cord
- body of femur
- atrium
- Gonadal ridge
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/9/97/PBB_GE_CALU_200755_s_at_fs.png/250px-PBB_GE_CALU_200755_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/6/64/PBB_GE_CALU_200756_x_at_fs.png/250px-PBB_GE_CALU_200756_x_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/PBB_GE_CALU_200757_s_at_fs.png/250px-PBB_GE_CALU_200757_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - calcium ion binding
- metal ion binding
- protein binding
| Cellular component | - Golgi apparatus
- endoplasmic reticulum membrane
- membrane
- melanosome
- sarcoplasmic reticulum
- extracellular region
- endoplasmic reticulum
- sarcoplasmic reticulum lumen
- endoplasmic reticulum lumen
| Biological process | - post-translational protein modification
- biological process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001130674 NM_001199671 NM_001199672 NM_001199673 NM_001199674
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NM_001219 |
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NM_001285412 NM_007594 NM_184053 |
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RefSeq (protein) | |
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NP_001124146 NP_001186600 NP_001186601 NP_001186602 NP_001210 |
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NP_001272341 NP_031620 NP_908942 |
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Location (UCSC) | Chr 7: 128.74 – 128.77 Mb | Chr 6: 29.35 – 29.38 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Calumenin is a protein that in humans is encoded by the CALU gene.[5][6]
Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000128595 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029767 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T (Aug 1998). "Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32". Genomics. 49 (2): 331–3. doi:10.1006/geno.1998.5245. PMID 9598325.
- ^ a b "Entrez Gene: CALU calumenin".
External links
Further reading
- Yabe D, Nakamura T, Kanazawa N, et al. (1997). "Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF". J. Biol. Chem. 272 (29): 18232–9. doi:10.1074/jbc.272.29.18232. PMID 9218460.
- Vorum H, Liu X, Madsen P, et al. (1998). "Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity". Biochim. Biophys. Acta. 1386 (1): 121–31. doi:10.1016/s0167-4838(98)00089-2. PMID 9675259.
- Hseu MJ, Yen CH, Tzeng MC (1999). "Crocalbin: a new calcium-binding protein that is also a binding protein for crotoxin, a neurotoxic phospholipase A2". FEBS Lett. 445 (2–3): 440–4. doi:10.1016/S0014-5793(99)00177-5. PMID 10094503. S2CID 40129100.
- Vorum H, Hager H, Christensen BM, et al. (1999). "Human calumenin localizes to the secretory pathway and is secreted to the medium". Exp. Cell Res. 248 (2): 473–81. doi:10.1006/excr.1999.4431. PMID 10222138.
- Vorum H, Jacobsen C, Honoré B (2000). "Calumenin interacts with serum amyloid P component". FEBS Lett. 465 (2–3): 129–34. doi:10.1016/S0014-5793(99)01734-2. PMID 10631319. S2CID 1943508.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.