DAZ associated protein 1

Protein-coding gene in the species Homo sapiens
DAZAP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DGS, 2DH8

Identifiers
AliasesDAZAP1, DAZ associated protein 1
External IDsOMIM: 607430; MGI: 1917498; HomoloGene: 137331; GeneCards: DAZAP1; OMA:DAZAP1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for DAZAP1
Genomic location for DAZAP1
Band19p13.3Start1,407,569 bp[1]
End1,435,687 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for DAZAP1
Genomic location for DAZAP1
Band10|10 C1Start80,097,320 bp[2]
End80,124,242 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • visceral pleura

  • mucosa of transverse colon

  • germinal epithelium

  • trabecular bone

  • olfactory zone of nasal mucosa

  • left ovary

  • granulocyte

  • right ovary
Top expressed in
  • neural layer of retina

  • yolk sac

  • spermatocyte

  • lip

  • ventricular zone

  • thymus

  • epiblast

  • renal corpuscle

  • ganglionic eminence

  • medullary collecting duct
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA stem-loop binding
  • nucleic acid binding
  • RNA binding
  • protein binding
  • poly(U) RNA binding
  • poly(G) binding
  • mRNA 3'-UTR binding
  • mRNA binding
Cellular component
  • nucleus
  • nucleoplasm
  • cytoplasm
  • cytosol
  • ribonucleoprotein complex
  • protein-containing complex
Biological process
  • multicellular organism development
  • maternal placenta development
  • cell population proliferation
  • cell differentiation
  • positive regulation of mRNA splicing, via spliceosome
  • spermatogenesis
  • germ cell development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26528

70248

Ensembl

ENSG00000071626

ENSMUSG00000069565

UniProt

Q96EP5

Q9JII5

RefSeq (mRNA)

NM_018959
NM_170711
NM_001352033
NM_001352034
NM_001352035

NM_001122604
NM_001122605
NM_133188
NM_001378995

RefSeq (protein)

NP_061832
NP_733829
NP_001338962
NP_001338963
NP_001338964

NP_001116076
NP_001116077
NP_573451
NP_001365924

Location (UCSC)Chr 19: 1.41 – 1.44 MbChr 10: 80.1 – 80.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene.[5][6]

Function

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.[6]

Interactions

DAZ associated protein 1 has been shown to interact with DAZ1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000071626 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069565 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (August 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.
  6. ^ a b "Entrez Gene: DAZAP1 DAZ associated protein 1".
  7. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

Further reading

  • Dai T, Vera Y, Salido EC, Yen PH (2003). "Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL". BMC Genomics. 2: 6. doi:10.1186/1471-2164-2-6. PMC 57980. PMID 11604102.
  • Vera Y, Dai T, Hikim AP, Lue Y, Salido EC, Swerdloff RS, Yen PH (2003). "Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation". J. Androl. 23 (5): 622–8. doi:10.1002/j.1939-4640.2002.tb02303.x. PMID 12185095. S2CID 2486961.
  • Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP (2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia". Leukemia. 19 (5): 806–13. doi:10.1038/sj.leu.2403684. PMID 15744350. S2CID 7228479.
  • Pan HA, Lin YS, Lee KH, Huang JR, Lin YH, Kuo PL (2006). "Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries". Fertil. Steril. 84 (Suppl 2): 1089–94. doi:10.1016/j.fertnstert.2005.03.075. PMID 16209998.
  • Morton S, Yang HT, Moleleki N, Campbell DG, Cohen P, Rousseau S (2006). "Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ". Biochem. J. 399 (2): 265–73. doi:10.1042/BJ20060681. PMC 1609909. PMID 16848763.
  • v
  • t
  • e
  • 2dgs: Solution structure of the second RNA binding domain in DAZ-associated protein 1
    2dgs: Solution structure of the second RNA binding domain in DAZ-associated protein 1
  • 2dh8: Solution structure of the N-terminal RNA binding domain in DAZ-associated protein 1
    2dh8: Solution structure of the N-terminal RNA binding domain in DAZ-associated protein 1


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