DBNDD2

Protein-coding gene in the species Homo sapiens
DBNDD2
Identifiers
AliasesDBNDD2, C20orf35, CK1BP, HSMNP1, dysbindin domain containing 2
External IDsOMIM: 611453; MGI: 106562; HomoloGene: 12276; GeneCards: DBNDD2; OMA:DBNDD2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for DBNDD2
Genomic location for DBNDD2
Band20q13.12Start45,406,057 bp[1]
End45,410,610 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for DBNDD2
Genomic location for DBNDD2
Band2 H3|2 85.17 cMStart164,328,026 bp[2]
End164,335,239 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • corpus callosum

  • substantia nigra

  • hippocampus proper

  • primary visual cortex

  • putamen

  • temporal lobe

  • amygdala

  • apex of heart

  • left ventricle
Top expressed in
  • lumbar subsegment of spinal cord

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • primary visual cortex

  • cerebellar cortex

  • lip

  • neural layer of retina

  • anterior horn of spinal cord

  • esophagus

  • right kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • synaptic vesicle membrane
Biological process
  • negative regulation of protein kinase activity
  • neuron projection development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55861

52840

Ensembl

ENSG00000244274

ENSMUSG00000017734

UniProt

Q9BQY9

Q9CRD4

RefSeq (mRNA)
NM_018478
NM_001048221
NM_001048222
NM_001048223
NM_001048224

NM_001048225
NM_001048226
NM_001197139
NM_001197140

NM_001048227
NM_001048228
NM_001048229
NM_026797

RefSeq (protein)
NP_001041686
NP_001041687
NP_001041688
NP_001041689
NP_001041690

NP_001041691
NP_001184068
NP_001184069
NP_060948

NP_001041692
NP_001041693
NP_001041694
NP_081073

Location (UCSC)Chr 20: 45.41 – 45.41 MbChr 2: 164.33 – 164.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dysbindin domain-containing protein 2 is a protein that in humans is encoded by the DBNDD2 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000244274 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017734 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2".

Further reading

  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Lucas T, Pratscher B, Fink D, et al. (2006). "The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12". Stem Cells Dev. 14 (5): 556–63. doi:10.1089/scd.2005.14.556. PMID 16305340.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Yin H, Laguna KA, Li G, Kuret J (2006). "Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1". Biochemistry. 45 (16): 5297–308. doi:10.1021/bi052354e. PMID 16618118.


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