DCBLD2

Protein-coding gene in the species Homo sapiens

DCBLD2
Identifiers
AliasesDCBLD2, CLCP1, ESDN, discoidin, CUB and LCCL domain containing 2
External IDsOMIM: 608698; MGI: 1920629; HomoloGene: 12499; GeneCards: DCBLD2; OMA:DCBLD2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for DCBLD2
Genomic location for DCBLD2
Band3q12.1|3Start98,795,941 bp[1]
End98,901,695 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for DCBLD2
Genomic location for DCBLD2
Band16|16 C1.2Start58,408,443 bp[2]
End58,469,727 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • vena cava

  • parotid gland

  • body of tongue

  • synovial joint

  • Skeletal muscle tissue of rectus abdominis

  • cardia

  • pons

  • mucosa of paranasal sinus

  • pylorus
Top expressed in
  • decidua

  • atrium

  • pineal gland

  • secondary oocyte

  • epithelium of stomach

  • primary oocyte

  • belly cord

  • external carotid artery

  • tail of embryo

  • endothelial cell of lymphatic vessel
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • cell surface
  • integral component of plasma membrane
  • membrane
Biological process
  • intracellular receptor signaling pathway
  • wound healing
  • negative regulation of cell growth
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

131566

73379

Ensembl

ENSG00000057019

ENSMUSG00000035107

UniProt

Q96PD2

Q91ZV3

RefSeq (mRNA)

NM_080927

NM_028523
NM_001356484

RefSeq (protein)

NP_563615

NP_082799
NP_001343413

Location (UCSC)Chr 3: 98.8 – 98.9 MbChr 16: 58.41 – 58.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Discoidin, CUB and LCCL domain-containing protein 2 is a protein that in humans is encoded by the DCBLD2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000057019 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035107 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kobuke K, Furukawa Y, Sugai M, Tanigaki K, Ohashi N, Matsumori A, Sasayama S, Honjo T, Tashiro K (Sep 2001). "ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury". The Journal of Biological Chemistry. 276 (36): 34105–14. doi:10.1074/jbc.M105293200. hdl:2433/150206. PMID 11447234.
  6. ^ "Entrez Gene: DCBLD2 discoidin, CUB and LCCL domain containing 2".

Further reading

  • Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al-Lamki RS, Takahashi T, Tellides G, Bender JR, Rodriguez ER (Sep 2007). "ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis". American Journal of Transplantation. 7 (9): 2098–105. doi:10.1111/j.1600-6143.2007.01919.x. PMID 17697260. S2CID 28463596.
  • Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP (Jul 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516. S2CID 23944956.
  • Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (Sep 2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Molecular & Cellular Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Koshikawa K, Osada H, Kozaki K, Konishi H, Masuda A, Tatematsu Y, Mitsudomi T, Nakao A, Takahashi T (Apr 2002). "Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo". Oncogene. 21 (18): 2822–8. doi:10.1038/sj.onc.1205405. PMID 11973641. S2CID 1747522.
  • Nadadur SS, Ehrke MJ, Gurtoo HL (Dec 1999). "A novel TNF-inducible message with putative growth suppressor function". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1489 (2–3): 433–9. doi:10.1016/s0167-4781(99)00189-x. PMID 10673047.


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